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Antibody Product Overview
| ELK.No | ES10337 |
| Product name | SYT7 rabbit pAb |
| Reactivity | Human;Mouse |
| Applications | WB;ELISA |
| Other name | |
| Size | 50μL |
| Unit price ($) | 148 |
| Human gene ID | 9066 |
| Human Swiss-Prot | O43581 |
| Source | Rabbit |
| Isotype | IgG |
| Target | SYT7 |
| Fields | |
| Gene name | SYT7 PCANAP7 |
| Protein name | Synaptotagmin-7 (IPCA-7) (Prostate cancer-associated protein 7) (Synaptotagmin VII) (SytVII) |
| Human gene link | |
| Human Swiss link | View Human Swiss-Prot |
| Mouse gene ID | |
| Mouse gene link | |
| Mouse Swiss-Prot | Q9R0N7 |
| Mouse Swiss link | View Mouse Swiss-Prot |
| Rat gene ID | |
| Rat gene link | |
| Rat Swiss-Prot | |
| Rat Swiss link | |
| Immunogen | Synthesized peptide derived from part region of human protein |
| Specificity | SYT7 Polyclonal Antibody detects endogenous levels of protein. |
| Formulation | Liquid in PBS containing 50% glycerol, and 0.02% sodium azide. |
| Clonality | Polyclonal |
| Dilution | WB 1:500-2000 ELISA 1:5000-20000 |
| Purification | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Concentration | 1 mg/ml |
| Storage stability | -20°C/1 year |
| Molecular Weight (Da) | |
| Observed band (KD) | 44kD |
| Background | This gene is a member of the synaptotagmin gene family and encodes a protein similar to other family members that mediate calcium-dependent regulation of membrane trafficking in synaptic transmission. A similar protein in rodents mediates hormone secretion and lysosome exocytosis. In humans, expression of this gene has been associated with prostate cancer. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Oct 2011], |
| Function | cofactor:Binds 3 calcium ions per subunit. The ions are bound to the C2 domains.,domain:The second C2 domain/C2B is responsible for SYNCRIP binding.,function:May be involved in Ca(2+)-dependent exocytosis of secretory vesicles through Ca(2+) and phospholipid binding to the C2 domain or may serve as Ca(2+) sensors in the process of vesicular trafficking and exocytosis.,similarity:Belongs to the synaptotagmin family.,similarity:Contains 2 C2 domains.,subunit:Interacts with SYNCRIP isoform 3 C-terminus.,tissue specificity:Expressed abundantly in brain (frontal and temporal lobes, hippocampus, hypothalamus, amygdala, substantia nigra, and pituitary), kidney, and prostate. Expressed in fetal brain, kidneys and lung.,tissue specificity:Expressed in a variety of adult and fetal tissues., |
| Subcellular location | Cell membrane ; Single-pass membrane protein . Cell junction, synapse, presynaptic cell membrane ; Single-pass membrane protein . Cytoplasmic vesicle, secretory vesicle, synaptic vesicle membrane ; Single-pass membrane protein . Lysosome membrane ; Single-pass membrane protein . Cytoplasmic vesicle, phagosome membrane ; Single-pass membrane protein . Peroxisome membrane ; Single-pass membrane protein . Cytoplasmic vesicle, secretory vesicle membrane ; Single-pass membrane protein . Localization to lysosomes is dependent on N-terminal palmitoylation and interaction with CD63. . |
| Expression | Expressed in a variety of adult and fetal tissues. |
Additional Images
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Western blot analysis of lysates from KB cells, primary antibody was diluted at 1:1000, 4°over night
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: AO-06-ES10337-50
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