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Cleaved-Ephrin-A2 (N188) rabbit pAb
AO-06-ES1037-100
Antibody Product Overview
| ELK.No | ES1037 |
| Product name | Cleaved-Ephrin-A2 (N188) rabbit pAb |
| Reactivity | Human;Mouse |
| Applications | WB;ELISA |
| Other name | EFNA2; EPLG6; LERK6; Ephrin-A2; EPH-related receptor tyrosine kinase ligand 6; LERK-6; HEK7 ligand; HEK7-L |
| Size | 100μL |
| Unit price ($) | 248 |
| Human gene ID | 1943 |
| Human Swiss-Prot | O43921 |
| Source | Rabbit |
| Isotype | IgG |
| Target | Ephrin-A2 |
| Fields | >>MAPK signaling pathway;>>Ras signaling pathway;>>Rap1 signaling pathway;>>PI3K-Akt signaling pathway;>>Axon guidance;>>MicroRNAs in cancer |
| Gene name | EFNA2 |
| Protein name | Ephrin-A2 |
| Human gene link | View Human Gene |
| Human Swiss link | View Human Swiss-Prot |
| Mouse gene ID | 13637 |
| Mouse gene link | View Mouse Gene |
| Mouse Swiss-Prot | P52801 |
| Mouse Swiss link | View Mouse Swiss-Prot |
| Rat gene ID | |
| Rat gene link | |
| Rat Swiss-Prot | |
| Rat Swiss link | |
| Immunogen | The antiserum was produced against synthesized peptide derived from human EFNA2. AA range:139-188 |
| Specificity | Cleaved-Ephrin-A2 (N188) Polyclonal Antibody detects endogenous levels of fragment of activated Ephrin-A2 protein resulting from cleavage adjacent to N188. |
| Formulation | Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide. |
| Clonality | Polyclonal |
| Dilution | Western Blot: 1/500 - 1/2000. ELISA: 1/20000. Not yet tested in other applications. |
| Purification | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Concentration | 1 mg/ml |
| Storage stability | -20°C/1 year |
| Molecular Weight (Da) | |
| Observed band (KD) | 21kD |
| Background | This gene encodes a member of the ephrin family. The protein is composed of a signal sequence, a receptor-binding region, a spacer region, and a hydrophobic region. The EPH and EPH-related receptors comprise the largest subfamily of receptor protein-tyrosine kinases and have been implicated in mediating developmental events, particularly in the nervous system. Based on their structures and sequence relationships, ephrins are divided into the ephrin-A (EFNA) class, which are anchored to the membrane by a glycosylphosphatidylinositol linkage, and the ephrin-B (EFNB) class, which are transmembrane proteins. Posttranslational modifications determine whether this protein localizes to the nucleus or the cytoplasm. [provided by RefSeq, Jul 2008], |
| Function | similarity:Belongs to the ephrin family.,subunit:Binds to the receptor tyrosine kinases EPHA3, EPHA4 and EPHA5., |
| Subcellular location | Cell membrane ; Lipid-anchor, GPI-anchor . |
| Expression | Brain, |
Additional Images
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Western Blot analysis of various cells using Cleaved-Ephrin-A2 (N188) Polyclonal Antibody
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Western blot analysis of lysates from 293 cells, treated with etoposide 25uM 1h, using EFNA2 (Cleaved-Asn188) Antibody. The lane on the right is blocked with the synthesized peptide.
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