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Cleaved-MMP-10 (F99) rabbit pAb
AO-06-ES1042-50
Antibody Product Overview
| ELK.No | ES1042 |
| Product name | Cleaved-MMP-10 (F99) rabbit pAb |
| Reactivity | Human;Rat;Mouse; |
| Applications | WB;ELISA |
| Other name | MMP10; STMY2; Stromelysin-2; SL-2; Matrix metalloproteinase-10; MMP-10; Transin-2 |
| Size | 50μL |
| Unit price ($) | 148 |
| Human gene ID | 4319 |
| Human Swiss-Prot | P09238 |
| Source | Rabbit |
| Isotype | IgG |
| Target | MMP-10 |
| Fields | |
| Gene name | MMP10 |
| Protein name | Stromelysin-2 |
| Human gene link | View Human Gene |
| Human Swiss link | View Human Swiss-Prot |
| Mouse gene ID | |
| Mouse gene link | |
| Mouse Swiss-Prot | O55123 |
| Mouse Swiss link | View Mouse Swiss-Prot |
| Rat gene ID | |
| Rat gene link | |
| Rat Swiss-Prot | |
| Rat Swiss link | |
| Immunogen | The antiserum was produced against synthesized peptide derived from human MMP10. AA range:80-129 |
| Specificity | Cleaved-MMP-10 (F99) Polyclonal Antibody detects endogenous levels of fragment of activated MMP-10 protein resulting from cleavage adjacent to F99. |
| Formulation | Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide. |
| Clonality | Polyclonal |
| Dilution | Western Blot: 1/500 - 1/2000. ELISA: 1/40000. Not yet tested in other applications. |
| Purification | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Concentration | 1 mg/ml |
| Storage stability | -20°C/1 year |
| Molecular Weight (Da) | |
| Observed band (KD) | 43kD |
| Background | This gene encodes a member of the peptidase M10 family of matrix metalloproteinases (MMPs). Proteins in this family are involved in the breakdown of extracellular matrix in normal physiological processes, such as embryonic development, reproduction, and tissue remodeling, as well as in disease processes, such as arthritis and metastasis. The encoded preproprotein is proteolytically processed to generate the mature protease. This secreted protease breaks down fibronectin, laminin, elastin, proteoglycan core protein, gelatins, and several types of collagen. The gene is part of a cluster of MMP genes on chromosome 11. [provided by RefSeq, Jan 2016], |
| Function | catalytic activity:Similar to stromelysin 1, but action on collagen types III, IV and V is weak.,cofactor:Binds 2 zinc ions per subunit.,cofactor:Calcium.,domain:The conserved cysteine present in the cysteine-switch motif binds the catalytic zinc ion, thus inhibiting the enzyme. The dissociation of the cysteine from the zinc ion upon the activation-peptide release activates the enzyme.,function:Can degrade fibronectin, gelatins of type I, III, IV, and V; weakly collagens III, IV, and V. Activates procollagenase.,similarity:Belongs to the peptidase M10A family.,similarity:Contains 4 hemopexin-like domains., |
| Subcellular location | Secreted, extracellular space, extracellular matrix . |
| Expression | Coronary artery,Ovary, |
Additional Images
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Western Blot analysis of various cells using Cleaved-MMP-10 (F99) Polyclonal Antibody diluted at 1:1000
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Western Blot analysis of HepG2 cells using Cleaved-MMP-10 (F99) Polyclonal Antibody diluted at 1:1000
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Western blot analysis of MMP10 (Cleaved-Phe99) Antibody. The lane on the right is blocked with the MMP10 (Cleaved-Phe99) peptide.
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: AO-06-ES1042-50
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