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Antibody Product Overview
| ELK.No | ES10648 |
| Product name | TSYL2 rabbit pAb |
| Reactivity | Human;Mouse |
| Applications | WB;ELISA |
| Other name | |
| Size | 50μL |
| Unit price ($) | 148 |
| Human gene ID | 64061 |
| Human Swiss-Prot | Q9H2G4 |
| Source | Rabbit |
| Isotype | IgG |
| Target | TSYL2 |
| Fields | |
| Gene name | TSPYL2 CDA1 DENTT TSPX HRIHFB2216 |
| Protein name | Testis-specific Y-encoded-like protein 2 (TSPY-like protein 2) (Cell division autoantigen 1) (Cutaneous T-cell lymphoma-associated antigen se20-4) (CTCL-associated antigen se20-4) (Differentially-expr |
| Human gene link | |
| Human Swiss link | View Human Swiss-Prot |
| Mouse gene ID | |
| Mouse gene link | |
| Mouse Swiss-Prot | Q7TQI8 |
| Mouse Swiss link | View Mouse Swiss-Prot |
| Rat gene ID | |
| Rat gene link | |
| Rat Swiss-Prot | |
| Rat Swiss link | |
| Immunogen | Synthesized peptide derived from part region of human protein |
| Specificity | TSYL2 Polyclonal Antibody detects endogenous levels of protein. |
| Formulation | Liquid in PBS containing 50% glycerol, and 0.02% sodium azide. |
| Clonality | Polyclonal |
| Dilution | WB 1:500-2000 ELISA 1:5000-20000 |
| Purification | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Concentration | 1 mg/ml |
| Storage stability | -20°C/1 year |
| Molecular Weight (Da) | |
| Observed band (KD) | 76kD |
| Background | This gene encodes a member of the testis-specific protein Y-encoded, TSPY-like/SET/nucleosome assembly protein-1 superfamily. The encoded protein is localized to the nucleolus where it functions in chromatin remodeling and as an inhibitor of cell-cycle progression. This protein may play a role in the suppression of tumor growth. [provided by RefSeq, Sep 2009], |
| Function | function:Part of the CASK/TRB1/TSPYL2 transcriptional complex which modulates gene expression in response to neuronal synaptic activity, probably by facilitating nucleosome assembly. May inhibit cell proliferation by inducing p53-dependent CDKN1A expression.,induction:Up-regulated in growth-arrested T-cells. Induced by TGFB1 and all-trans retinoic acid in lung cancer cells (at protein level).,miscellaneous:Subject to X inactivation.,miscellaneous:Synaptic activity down-regulates TSPYL2 protein levels by inducing rapid proteasomal degradation.,PTM:Phosphorylation at Ser-20 and/or Thr-340 impairs function on cell proliferation.,similarity:Belongs to the nucleosome assembly protein (NAP) family.,subcellular location:Enriched in transcriptionally active regions of chromatin in neurons.,subunit:Interacts with histones. Interacts with CASK. Part of a complex containing CASK, TRB1 and TSPYL2.,t |
| Subcellular location | Nucleus . Cytoplasm . Enriched in transcriptionally active regions of chromatin in neurons. . |
| Expression | Ubiquitously expressed, with highest levels in brain, testis and heart, and lowest levels in liver and pancreas. |
Additional Images
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Western Blot analysis of Hela lysis, using primary antibody at 1:1000 dilution. Secondary antibody(catalog#:RS23920) was diluted at 1:10000
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: AO-06-ES10648-50
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