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Antibody Product Overview
| ELK.No | ES10948 |
| Product name | CDO1 rabbit pAb |
| Reactivity | Human;Mouse;Rat |
| Applications | WB;ELISA |
| Other name | |
| Size | 100μL |
| Unit price ($) | 248 |
| Human gene ID | 1036 |
| Human Swiss-Prot | Q16878 |
| Source | Rabbit |
| Isotype | IgG |
| Target | CDO1 |
| Fields | >>Cysteine and methionine metabolism;>>Taurine and hypotaurine metabolism;>>Metabolic pathways |
| Gene name | CDO1 |
| Protein name | Cysteine dioxygenase type 1 (EC 1.13.11.20) (Cysteine dioxygenase type I) (CDO) (CDO-I) |
| Human gene link | |
| Human Swiss link | View Human Swiss-Prot |
| Mouse gene ID | |
| Mouse gene link | |
| Mouse Swiss-Prot | P60334 |
| Mouse Swiss link | View Mouse Swiss-Prot |
| Rat gene ID | |
| Rat gene link | |
| Rat Swiss-Prot | P21816 |
| Rat Swiss link | View Rat Swiss-Prot |
| Immunogen | Synthesized peptide derived from part region of human protein |
| Specificity | CDO1 Polyclonal Antibody detects endogenous levels of protein. |
| Formulation | Liquid in PBS containing 50% glycerol, and 0.02% sodium azide. |
| Clonality | Polyclonal |
| Dilution | WB 1:500-2000 ELISA 1:5000-20000 |
| Purification | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Concentration | 1 mg/ml |
| Storage stability | -20°C/1 year |
| Molecular Weight (Da) | |
| Observed band (KD) | 27kD |
| Background | catalytic activity:L-cysteine + O(2) = 3-sulfinoalanine.,cofactor:Binds 1 iron ion per subunit. Zinc to a much lesser extent.,cofactor:IRON; NAD(P)H.,function:Initiates several important metabolic pathways related to pyruvate and several sulfurate compounds including sulfate, hypotaurine and taurine. Critical regulator of cellular cysteine concentrations. Has an important role in maintaining the hepatic concentation of intracellular free cysteine within a proper narrow range.,induction:In hepatoblastoma HepG2 cells, down-regulated by phorbol 12-myristate 13-acetate.,pathway:Organosulfur biosynthesis; taurine biosynthesis; hypotaurine from L-cysteine: step 1/2.,PTM:The thioether cross-link between Cys-93 and Tyr-157 plays a structural role through stabilizing the Fe(2+) ion, and prevents the production of highly damaging free hydroxyl radicals by holding the oxygen radical via hydroxyl hydrogen.,similarity:Belongs to the cysteine dioxygenase family.,subunit:Monomer.,tissue specificity:Highly expressed in liver and placenta. Low expression in heart, brain and pancreas. Also detected in hepatoblastoma HepG2 cells., |
| Function | catalytic activity:L-cysteine + O(2) = 3-sulfinoalanine.,cofactor:Binds 1 iron ion per subunit. Zinc to a much lesser extent.,cofactor:IRON; NAD(P)H.,function:Initiates several important metabolic pathways related to pyruvate and several sulfurate compounds including sulfate, hypotaurine and taurine. Critical regulator of cellular cysteine concentrations. Has an important role in maintaining the hepatic concentation of intracellular free cysteine within a proper narrow range.,induction:In hepatoblastoma HepG2 cells, down-regulated by phorbol 12-myristate 13-acetate.,pathway:Organosulfur biosynthesis; taurine biosynthesis; hypotaurine from L-cysteine: step 1/2.,PTM:The thioether cross-link between Cys-93 and Tyr-157 plays a structural role through stabilizing the Fe(2+) ion, and prevents the production of highly damaging free hydroxyl radicals by holding the oxygen radical via hydroxyl hy |
| Subcellular location | cytosol, |
| Expression | Highly expressed in liver and placenta. Low expression in heart, brain and pancreas. Also detected in hepatoblastoma Hep-G2 cells. |
Additional Images
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Western blot analysis of lysates from DU145 cells, primary antibody was diluted at 1:1000, 4°over night
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: AO-06-ES10948-100
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