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Antibody Product Overview
| ELK.No | ES10998 |
| Product name | FKBP8 rabbit pAb |
| Reactivity | Human;Mouse;Rat |
| Applications | WB;ELISA |
| Other name | |
| Size | 50μL |
| Unit price ($) | 148 |
| Human gene ID | 23770 |
| Human Swiss-Prot | Q14318 |
| Source | Rabbit |
| Isotype | IgG |
| Target | FKBP8 |
| Fields | |
| Gene name | FKBP8 FKBP38 |
| Protein name | Peptidyl-prolyl cis-trans isomerase FKBP8 (PPIase FKBP8) (EC 5.2.1.8) (38 kDa FK506-binding protein) (38 kDa FKBP) (FKBP-38) (hFKBP38) (FK506-binding protein 8) (FKBP-8) (FKBPR38) (Rotamase) |
| Human gene link | |
| Human Swiss link | View Human Swiss-Prot |
| Mouse gene ID | |
| Mouse gene link | |
| Mouse Swiss-Prot | O35465 |
| Mouse Swiss link | View Mouse Swiss-Prot |
| Rat gene ID | |
| Rat gene link | |
| Rat Swiss-Prot | Q3B7U9 |
| Rat Swiss link | View Rat Swiss-Prot |
| Immunogen | Synthesized peptide derived from part region of human protein |
| Specificity | FKBP8 Polyclonal Antibody detects endogenous levels of protein. |
| Formulation | Liquid in PBS containing 50% glycerol, and 0.02% sodium azide. |
| Clonality | Polyclonal |
| Dilution | WB 1:500-2000 ELISA 1:5000-20000 |
| Purification | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Concentration | 1 mg/ml |
| Storage stability | -20°C/1 year |
| Molecular Weight (Da) | |
| Observed band (KD) | 45kD |
| Background | The protein encoded by this gene is a member of the immunophilin protein family, which play a role in immunoregulation and basic cellular processes involving protein folding and trafficking. Unlike the other members of the family, this encoded protein does not seem to have PPIase/rotamase activity. It may have a role in neurons associated with memory function. [provided by RefSeq, Jul 2008], |
| Function | catalytic activity:Peptidylproline (omega=180) = peptidylproline (omega=0).,caution:It is uncertain whether Met-1 or Met-58 is the initiator.,cofactor:Calcium.,function:Constitutively inactive PPiase, which becomes active when bound to calmodulin and calcium. Seems to act as a chaperone for BCL2, targets it to the mitochondria and modulates its phosphorylation state. The BCL2/FKBP8/calmodulin/calcium complex probably interferes with the binding of BCL2 to its targets. The active form of FKBP8 may therefore play a role in the regulation of apoptosis.,miscellaneous:Binds the immunosuppressant FK506 only in its calmodulin/calcium activated form.,sequence caution:The first part of the cDNA maps to the same locus, but in opposite orientation.,similarity:Contains 1 PPIase FKBP-type domain.,similarity:Contains 3 TPR repeats.,subunit:Homomultimers or heteromultimers (Potential). Forms heterodime |
| Subcellular location | Mitochondrion . Mitochondrion membrane ; Single-pass membrane protein; Cytoplasmic side .; [Isoform 1]: Mitochondrion membrane ; Single-pass membrane protein; Cytoplasmic side .; [Isoform 3]: Mitochondrion membrane ; Single-pass membrane protein; Cytoplasmic side . |
| Expression | Widely expressed. Highest levels seen in the brain. Highly abundant in the retina. |
Additional Images
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Western blot analysis of lysates from KB cells, primary antibody was diluted at 1:1000, 4°over night
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: AO-06-ES10998-50
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