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Antibody Product Overview
| ELK.No | ES11132 |
| Product name | CLC1B rabbit pAb |
| Reactivity | Human;Mouse |
| Applications | WB;ELISA |
| Other name | |
| Size | 100μL |
| Unit price ($) | 248 |
| Human gene ID | 51266 |
| Human Swiss-Prot | Q9P126 |
| Source | Rabbit |
| Isotype | IgG |
| Target | CLC1B |
| Fields | >>C-type lectin receptor signaling pathway |
| Gene name | CLEC1B CLEC2 UNQ721/PRO1384 |
| Protein name | C-type lectin domain family 1 member B (C-type lectin-like receptor 2) (CLEC-2) |
| Human gene link | |
| Human Swiss link | View Human Swiss-Prot |
| Mouse gene ID | |
| Mouse gene link | |
| Mouse Swiss-Prot | Q9JL99 |
| Mouse Swiss link | View Mouse Swiss-Prot |
| Rat gene ID | |
| Rat gene link | |
| Rat Swiss-Prot | |
| Rat Swiss link | |
| Immunogen | Synthesized peptide derived from part region of human protein |
| Specificity | CLC1B Polyclonal Antibody detects endogenous levels of protein. |
| Formulation | Liquid in PBS containing 50% glycerol, and 0.02% sodium azide. |
| Clonality | Polyclonal |
| Dilution | WB 1:500-2000 ELISA 1:5000-20000 |
| Purification | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Concentration | 1 mg/ml |
| Storage stability | -20°C/1 year |
| Molecular Weight (Da) | |
| Observed band (KD) | 25kD |
| Background | Natural killer (NK) cells express multiple calcium-dependent (C-type) lectin-like receptors, such as CD94 (KLRD1; MIM 602894) and NKG2D (KLRC4; MIM 602893), that interact with major histocompatibility complex class I molecules and either inhibit or activate cytotoxicity and cytokine secretion. CLEC2 is a C-type lectin-like receptor expressed in myeloid cells and NK cells (Colonna et al., 2000 [PubMed 10671229]).[supplied by OMIM, Jan 2011], |
| Function | function:Acts as a receptor for the platelet-aggregating snake venom protein rhodocytin. Rhodocytin binding leads to tyrosine phosphorylation and this promotes the binding of spleen tyrosine kinase (Syk) and initiation of downstream tyrosine phosphorylation events and activation of PLC-gamma-2. Acts as an attachment factor for human immunodeficiency virus type 1 (HIV-1) and facilitates its capture by platelets.,online information:CLEC-2,PTM:Glycosylated.,PTM:Phosphorylated on tyrosine residue in response to rhodocytin binding.,similarity:Contains 1 C-type lectin domain.,subunit:Monomer.,tissue specificity:Expressed preferentially in the liver. Also expressed in immune cells of myeloid origin and on the surface of platelets., |
| Subcellular location | Membrane ; Single-pass type II membrane protein . |
| Expression | Expressed preferentially in the liver. Also expressed in immune cells of myeloid origin and on the surface of platelets. |
Additional Images
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Western blot analysis of lysates from K562 cells, primary antibody was diluted at 1:1000, 4°over night
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: AO-06-ES11132-100
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