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Antibody Product Overview
| ELK.No | ES11152 |
| Product name | PRDX6 rabbit pAb |
| Reactivity | Human;Rat;Mouse |
| Applications | WB;ELISA |
| Other name | |
| Size | 50μL |
| Unit price ($) | 148 |
| Human gene ID | 9588 |
| Human Swiss-Prot | P30041 |
| Source | Rabbit |
| Isotype | IgG |
| Target | PRDX6 |
| Fields | >>Glutathione metabolism;>>Metabolic pathways |
| Gene name | PRDX6 AOP2 KIAA0106 |
| Protein name | Peroxiredoxin-6 (EC 1.11.1.15) (1-Cys peroxiredoxin) (1-Cys PRX) (24 kDa protein) (Acidic calcium-independent phospholipase A2) (aiPLA2) (EC 3.1.1.-) (Antioxidant protein 2) (Liver 2D page spot 40) (N |
| Human gene link | |
| Human Swiss link | View Human Swiss-Prot |
| Mouse gene ID | |
| Mouse gene link | |
| Mouse Swiss-Prot | O08709 |
| Mouse Swiss link | View Mouse Swiss-Prot |
| Rat gene ID | |
| Rat gene link | |
| Rat Swiss-Prot | O35244 |
| Rat Swiss link | View Rat Swiss-Prot |
| Immunogen | Synthesized peptide derived from part region of human protein |
| Specificity | PRDX6 Polyclonal Antibody detects endogenous levels of protein. |
| Formulation | Liquid in PBS containing 50% glycerol, and 0.02% sodium azide. |
| Clonality | Polyclonal |
| Dilution | WB 1:500-2000 ELISA 1:5000-20000 |
| Purification | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Concentration | 1 mg/ml |
| Storage stability | -20°C/1 year |
| Molecular Weight (Da) | |
| Observed band (KD) | 24kD |
| Background | The protein encoded by this gene is a member of the thiol-specific antioxidant protein family. This protein is a bifunctional enzyme with two distinct active sites. It is involved in redox regulation of the cell; it can reduce H(2)O(2) and short chain organic, fatty acid, and phospholipid hydroperoxides. It may play a role in the regulation of phospholipid turnover as well as in protection against oxidative injury. [provided by RefSeq, Jul 2008], |
| Function | catalytic activity:2 R'-SH + ROOH = R'-S-S-R' + H(2)O + ROH.,catalytic activity:Donor + H(2)O(2) = oxidized donor + 2 H(2)O.,function:Involved in redox regulation of the cell. Can reduce H(2)O(2) and short chain organic, fatty acid, and phospholipid hydroperoxides. May play a role in the regulation of phospholipid turnover as well as in protection against oxidative injury.,miscellaneous:Irreversibly inactivated by overoxidation of Cys-47 (to Cys-SO(3)H) upon oxidative stress.,miscellaneous:The active site is the redox-active Cys-47 oxidized to Cys-SOH. Cys-SOH may rapidly react with a Cys-SH of the other subunit to form an intermolecular disulfide with a concomitant homodimer formation. The enzyme may be subsequently regenerated by reduction of the disulfide by thioredoxin.,similarity:Belongs to the ahpC/TSA family. Rehydrin subfamily.,similarity:Contains 1 thioredoxin domain.,subcellula |
| Subcellular location | Cytoplasm . Lysosome . Also found in lung secretory organelles (lamellar bodies). . |
| Expression | Bone marrow,Brain,Cajal-Retzius cell,Erythrocyte,Fetal brain,Fetal brain cortex,Liver,Plate |
Additional Images
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Western blot analysis of lysates from U2OS cells, primary antibody was diluted at 1:1000, 4°over night
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: AO-06-ES11152-50
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