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Antibody Product Overview
| ELK.No | ES11307 |
| Product name | DLL3 rabbit pAb |
| Reactivity | Human;Mouse;Rat |
| Applications | WB;ELISA |
| Other name | |
| Size | 50μL |
| Unit price ($) | 148 |
| Human gene ID | 10683 |
| Human Swiss-Prot | Q9NYJ7 |
| Source | Rabbit |
| Isotype | IgG |
| Target | DLL3 |
| Fields | >>Endocrine resistance;>>Notch signaling pathway;>>Th1 and Th2 cell differentiation;>>Pathways in cancer;>>Chemical carcinogenesis - receptor activation;>>Breast cancer |
| Gene name | DLL3 |
| Protein name | Delta-like protein 3 (Drosophila Delta homolog 3) (Delta3) |
| Human gene link | |
| Human Swiss link | View Human Swiss-Prot |
| Mouse gene ID | |
| Mouse gene link | |
| Mouse Swiss-Prot | O88516 |
| Mouse Swiss link | View Mouse Swiss-Prot |
| Rat gene ID | |
| Rat gene link | |
| Rat Swiss-Prot | O88671 |
| Rat Swiss link | View Rat Swiss-Prot |
| Immunogen | Synthesized peptide derived from human protein . at AA range: 510-590 |
| Specificity | DLL3 Polyclonal Antibody detects endogenous levels of protein. |
| Formulation | Liquid in PBS containing 50% glycerol, and 0.02% sodium azide. |
| Clonality | Polyclonal |
| Dilution | WB 1:500-2000 ELISA 1:5000-20000 |
| Purification | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Concentration | 1 mg/ml |
| Storage stability | -20°C/1 year |
| Molecular Weight (Da) | |
| Observed band (KD) | 67kD |
| Background | This gene encodes a member of the delta protein ligand family. This family functions as Notch ligands that are characterized by a DSL domain, EGF repeats, and a transmembrane domain. Mutations in this gene cause autosomal recessive spondylocostal dysostosis 1. Two transcript variants encoding distinct isoforms have been identified for this gene. [provided by RefSeq, Jul 2008], |
| Function | disease:Defects in DLL3 are the cause of spondylocostal dysostosis autosomal recessive type 1 (SCDO1) [MIM:277300]. Autosomal recessive spondylocostal dysostosis is a rare condition of variable severity associated with vertebral and rib segmentation defects. The main skeletal malformations include fusion of vertebrae, hemivertebrae, fusion of certain ribs, and other rib malformations. Deformity of the chest and spine (severe scoliosis, kyphoscoliosis and lordosis) is a natural consequence of the malformation and leads to a dwarf-like appearance. As the thorax is small, infants frequently have respiratory insufficiency and repeated respiratory infections resulting in life-threatening complications in the first year of life.,domain:The DSL domain is required for binding to the Notch receptor.,function:Inhibits primary neurogenesis. May be required to divert neurons along a specific differe |
| Subcellular location | Membrane ; Single-pass type I membrane protein . |
| Expression | Brain, |
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: AO-06-ES11307-50
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