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Antibody Product Overview
| ELK.No | ES11422 |
| Product name | ZBP1 rabbit pAb |
| Reactivity | Human;Rat;Mouse; |
| Applications | WB;ELISA |
| Other name | |
| Size | 50μL |
| Unit price ($) | 148 |
| Human gene ID | 81030 |
| Human Swiss-Prot | Q9H171 |
| Source | Rabbit |
| Isotype | IgG |
| Target | ZBP1 |
| Fields | >>Necroptosis;>>Cytosolic DNA-sensing pathway |
| Gene name | ZBP1 C20orf183 DLM1 |
| Protein name | Z-DNA-binding protein 1 (Tumor stroma and activated macrophage protein DLM-1) |
| Human gene link | |
| Human Swiss link | View Human Swiss-Prot |
| Mouse gene ID | |
| Mouse gene link | |
| Mouse Swiss-Prot | Q9QY24 |
| Mouse Swiss link | View Mouse Swiss-Prot |
| Rat gene ID | |
| Rat gene link | |
| Rat Swiss-Prot | Q8VDA5 |
| Rat Swiss link | View Rat Swiss-Prot |
| Immunogen | Synthesized peptide derived from human protein . at AA range: 21-70 |
| Specificity | ZBP1 Polyclonal Antibody detects endogenous levels of protein. |
| Formulation | Liquid in PBS containing 50% glycerol, and 0.02% sodium azide. |
| Clonality | Polyclonal |
| Dilution | WB 1:500-2000 ELISA 1:5000-20000 |
| Purification | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Concentration | 1 mg/ml |
| Storage stability | -20°C/1 year |
| Molecular Weight (Da) | |
| Observed band (KD) | 47kD |
| Background | This gene encodes a Z-DNA binding protein. The encoded protein plays a role in the innate immune response by binding to foreign DNA and inducing type-I interferon production. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Dec 2011], |
| Function | alternative products:Additional isoforms seem to exist,function:May play a role in host defense against tumors and pathogens. Binds Z-DNA.,similarity:Contains 2 DRADA repeats.,tissue specificity:Highly expressed in lymphatic tissues including lymph node, leukocytes, tonsil, bone marrow and spleen. Expressed to a lesser extent in thymus, lung and liver., |
| Subcellular location | Cytoplasm . Nucleus . Mainly cytoplasmic (PubMed:16876127, PubMed:16990255). Accumulates in the nucleus in response to influenza A virus (IAV) infection: senses IAV defective viral genomes RNA in the nucleus (By similarity). .; [Isoform 7]: Cytoplasm . Nucleus . Compared to isoform 1, a higher proportion of this isoform is localized in the nucleus. . |
| Expression | Highly expressed in lymphatic tissues including lymph node, leukocytes, tonsil, bone marrow and spleen (PubMed:11842111). Expressed to a lesser extent in thymus, lung and liver (PubMed:11842111). |
Additional Images
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Western blot analysis of lysates from SW480 cells, primary antibody was diluted at 1:1000, 4°over night
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: AO-06-ES11422-50
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