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Antibody Product Overview
| ELK.No | ES11508 |
| Product name | MRGRD rabbit pAb |
| Reactivity | Human;Rat;Mouse; |
| Applications | WB;ELISA |
| Other name | |
| Size | 50μL |
| Unit price ($) | 148 |
| Human gene ID | 116512 |
| Human Swiss-Prot | Q8TDS7 |
| Source | Rabbit |
| Isotype | IgG |
| Target | MRGRD |
| Fields | >>Renin-angiotensin system |
| Gene name | MRGPRD MRGD |
| Protein name | Mas-related G-protein coupled receptor member D (Beta-alanine receptor) (G-protein coupled receptor TGR7) |
| Human gene link | |
| Human Swiss link | View Human Swiss-Prot |
| Mouse gene ID | |
| Mouse gene link | |
| Mouse Swiss-Prot | Q91ZB8 |
| Mouse Swiss link | View Mouse Swiss-Prot |
| Rat gene ID | |
| Rat gene link | |
| Rat Swiss-Prot | Q7TN41 |
| Rat Swiss link | View Rat Swiss-Prot |
| Immunogen | Synthesized peptide derived from part region of human protein |
| Specificity | MRGRD Polyclonal Antibody detects endogenous levels of protein. |
| Formulation | Liquid in PBS containing 50% glycerol, and 0.02% sodium azide. |
| Clonality | Polyclonal |
| Dilution | WB 1:500-2000 ELISA 1:5000-20000 |
| Purification | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Concentration | 1 mg/ml |
| Storage stability | -20°C/1 year |
| Molecular Weight (Da) | |
| Observed band (KD) | 35kD |
| Background | function:May regulate nociceptor function and/or development, including the sensation or modulation of pain. Functions as a specific membrane receptor for beta-alanine. Beta-alanine at micromolar doses specifically evoked Ca(2+) influx in cells expressing the receptor. Beta-alanine decreases forskolin-stimulated cAMP production in cells expressing the receptor, suggesting that the receptor couples with G-protein G(q) and G(i).,similarity:Belongs to the G-protein coupled receptor 1 family. Mas subfamily.,subcellular location:Localized at the plasma membrane but internalized into the cytoplasm after treatment with beta-alanine., |
| Function | function:May regulate nociceptor function and/or development, including the sensation or modulation of pain. Functions as a specific membrane receptor for beta-alanine. Beta-alanine at micromolar doses specifically evoked Ca(2+) influx in cells expressing the receptor. Beta-alanine decreases forskolin-stimulated cAMP production in cells expressing the receptor, suggesting that the receptor couples with G-protein G(q) and G(i).,similarity:Belongs to the G-protein coupled receptor 1 family. Mas subfamily.,subcellular location:Localized at the plasma membrane but internalized into the cytoplasm after treatment with beta-alanine., |
| Subcellular location | Cell membrane ; Multi-pass membrane protein . Localized at the plasma membrane but internalized into the cytoplasm after treatment with beta-alanine. |
| Expression | Liver, |
Additional Images
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Western blot analysis of lysates from SW480 cells, primary antibody was diluted at 1:1000, 4°over night
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: AO-06-ES11508-50
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