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Antibody Product Overview
| ELK.No | ES11638 |
| Product name | TA2R rabbit pAb |
| Reactivity | Human;Rat;Mouse |
| Applications | WB;ELISA |
| Other name | |
| Size | 50μL |
| Unit price ($) | 148 |
| Human gene ID | 6915 |
| Human Swiss-Prot | P21731 |
| Source | Rabbit |
| Isotype | IgG |
| Target | TA2R |
| Fields | >>Calcium signaling pathway;>>Neuroactive ligand-receptor interaction;>>Platelet activation |
| Gene name | TBXA2R |
| Protein name | Thromboxane A2 receptor (TXA2-R) (Prostanoid TP receptor) |
| Human gene link | |
| Human Swiss link | View Human Swiss-Prot |
| Mouse gene ID | |
| Mouse gene link | |
| Mouse Swiss-Prot | P30987 |
| Mouse Swiss link | View Mouse Swiss-Prot |
| Rat gene ID | |
| Rat gene link | |
| Rat Swiss-Prot | P34978 |
| Rat Swiss link | View Rat Swiss-Prot |
| Immunogen | Synthesized peptide derived from human protein . at AA range: 230-310 |
| Specificity | TA2R Polyclonal Antibody detects endogenous levels of protein. |
| Formulation | Liquid in PBS containing 50% glycerol, and 0.02% sodium azide. |
| Clonality | Polyclonal |
| Dilution | WB 1:500-2000 ELISA 1:5000-20000 |
| Purification | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Concentration | 1 mg/ml |
| Storage stability | -20°C/1 year |
| Molecular Weight (Da) | |
| Observed band (KD) | 37kD |
| Background | thromboxane A2 receptor(TBXA2R) Homo sapiens This gene encodes a member of the G protein-coupled receptor family. The protein interacts with thromboxane A2 to induce platelet aggregation and regulate hemostasis. A mutation in this gene results in a bleeding disorder. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Oct 2009], |
| Function | disease:Defects in TBXA2R are the cause of a dominantly inherited bleeding disorder [MIM:188070].,function:Receptor for thromboxane A2 (TXA2), a potent stimulator of platelet aggregation. The activity of this receptor is mediated by a G-protein that activates a phosphatidylinositol-calcium second messenger system. In the kidney, the binding of TXA2 to glomerular TP receptors causes intense vasoconstriction. Activates phospholipase C. Isoform 1 activates adenylyl cyclase, isoform 2 inhibits adenylyl cyclase.,similarity:Belongs to the G-protein coupled receptor 1 family., |
| Subcellular location | Cell membrane; Multi-pass membrane protein. |
| Expression | Blood,Endothelial cell,Lung,PCR rescued clones,Placenta,Platelet, |
Additional Images
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Western blot analysis of lysates from PC12 cells, primary antibody was diluted at 1:1000, 4°over night
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: AO-06-ES11638-50
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