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Antibody Product Overview
| ELK.No | ES11903 |
| Product name | GSHB rabbit pAb |
| Reactivity | Human;Mouse;Rat |
| Applications | WB;ELISA |
| Other name | |
| Size | 100μL |
| Unit price ($) | 248 |
| Human gene ID | 2937 |
| Human Swiss-Prot | P48637 |
| Source | Rabbit |
| Isotype | IgG |
| Target | GSHB |
| Fields | >>Cysteine and methionine metabolism;>>Glutathione metabolism;>>Metabolic pathways;>>Biosynthesis of cofactors;>>Ferroptosis |
| Gene name | GSS |
| Protein name | Glutathione synthetase (GSH synthetase) (GSH-S) (EC 6.3.2.3) (Glutathione synthase) |
| Human gene link | |
| Human Swiss link | View Human Swiss-Prot |
| Mouse gene ID | |
| Mouse gene link | |
| Mouse Swiss-Prot | P51855 |
| Mouse Swiss link | View Mouse Swiss-Prot |
| Rat gene ID | |
| Rat gene link | |
| Rat Swiss-Prot | P46413 |
| Rat Swiss link | View Rat Swiss-Prot |
| Immunogen | Synthesized peptide derived from part region of human protein |
| Specificity | GSHB Polyclonal Antibody detects endogenous levels of protein. |
| Formulation | Liquid in PBS containing 50% glycerol, and 0.02% sodium azide. |
| Clonality | Polyclonal |
| Dilution | WB 1:500-2000 ELISA 1:5000-20000 |
| Purification | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Concentration | 1 mg/ml |
| Storage stability | -20°C/1 year |
| Molecular Weight (Da) | |
| Observed band (KD) | 52kD |
| Background | Glutathione is important for a variety of biological functions, including protection of cells from oxidative damage by free radicals, detoxification of xenobiotics, and membrane transport. The protein encoded by this gene functions as a homodimer to catalyze the second step of glutathione biosynthesis, which is the ATP-dependent conversion of gamma-L-glutamyl-L-cysteine to glutathione. Defects in this gene are a cause of glutathione synthetase deficiency. [provided by RefSeq, Jul 2008], |
| Function | catalytic activity:ATP + gamma-L-glutamyl-L-cysteine + glycine = ADP + phosphate + glutathione.,disease:Defects in GSS are the cause of glutathione synthetase deficiency (GSS deficiency) [MIM:266130]; referred to as 5-oxoprolinuria. It is a severe form characterized by an increased rate of hemolysis and defective function of the central nervous system.,disease:Defects in GSS are the cause of glutathione synthetase deficiency of erythrocytes [MIM:231900]. It is a mild form causing hemolytic anemia.,pathway:Sulfur metabolism; glutathione biosynthesis; glutathione from L-cysteine and L-glutamate: step 2/2.,similarity:Belongs to the eukaryotic GSH synthase family.,subunit:Homodimer., |
| Subcellular location | cytosol,extracellular exosome, |
| Expression | Brain,Fetal brain cortex,Kidney,Lung, |
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: AO-06-ES11903-100
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