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Antibody Product Overview
| ELK.No | ES12198 |
| Product name | ZMIZ2 rabbit pAb |
| Reactivity | Human; Mouse |
| Applications | WB |
| Other name | |
| Size | 50μL |
| Unit price ($) | 148 |
| Human gene ID | 83637 |
| Human Swiss-Prot | Q8NF64 |
| Source | Rabbit |
| Isotype | IgG |
| Target | ZMIZ2 |
| Fields | |
| Gene name | ZMIZ2 KIAA1886 ZIMP7 HRIHFB2007 |
| Protein name | ZMIZ2 |
| Human gene link | View Human Gene |
| Human Swiss link | View Human Swiss-Prot |
| Mouse gene ID | 52915 |
| Mouse gene link | View Mouse Gene |
| Mouse Swiss-Prot | Q8CIE2 |
| Mouse Swiss link | View Mouse Swiss-Prot |
| Rat gene ID | |
| Rat gene link | |
| Rat Swiss-Prot | |
| Rat Swiss link | |
| Immunogen | Synthesized peptide derived from human ZMIZ2 AA range: 512-562 |
| Specificity | This antibody detects endogenous levels of ZMIZ2 at Human/Mouse |
| Formulation | Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide. |
| Clonality | Polyclonal |
| Dilution | WB 1：500-2000 |
| Purification | The antibody was affinity-purified from rabbit serum by affinity-chromatography using specific immunogen. |
| Concentration | 1 mg/ml |
| Storage stability | -20°C/1 year |
| Molecular Weight (Da) | 101kD |
| Observed band (KD) | |
| Background | ZMIZ2 and ZMIZ1 (MIM 607159) are members of a PIAS (see MIM 603566)-like family of proteins that interact with nuclear hormone receptors. ZMIZ2 interacts with androgen receptor (AR; MIM 313700) and enhances AR-mediated transcription (Huang et al., 2005 [PubMed 16051670]).[supplied by OMIM, May 2010], |
| Function | domain:The C-terminal proline-rich domain possesses a significant intrinsic transcriptional activity. This activity is inhibited by the N-terminus in the full-length protein.,function:Increases ligand-dependent transcriptional activity of AR and other nuclear hormone receptors.,similarity:Contains 1 SP-RING-type zinc finger.,subcellular location:Detected at replication foci throughout S phase.,subunit:Interacts with AR, SMARCA4/BRG1 and SMARCE1/BAF57. Interaction with either SMARCA4 and SMARCE1 enhances AR-mediated transcription.,tissue specificity:Expressed most abundantly in testis with lower levels in heart, brain, pancreas, prostate and ovary., |
| Subcellular location | Nucleus . Detected at replication foci throughout S phase. |
| Expression | Expressed most abundantly in testis with lower levels in heart, brain, pancreas, prostate and ovary. |
Additional Images
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Western blot analysis of lysates from VEC cells, primary antibody was diluted at 1:1000, 4°over night
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: AO-06-ES12198-50
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