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Antibody Product Overview
| ELK.No | ES12217 |
| Product name | ZDHC8 rabbit pAb |
| Reactivity | Human; Mouse |
| Applications | WB |
| Other name | Probable palmitoyltransferase ZDHHC8 (EC 2.3.1.-) (Zinc finger DHHC domain-containing protein 8) (DHHC-8) (Zinc finger protein 378) |
| Size | 100μL |
| Unit price ($) | 248 |
| Human gene ID | 29801 |
| Human Swiss-Prot | Q9ULC8 |
| Source | Rabbit |
| Isotype | IgG |
| Target | ZDHC8 |
| Fields | |
| Gene name | ZDHHC8 KIAA1292 ZDHHCL1 ZNF378 |
| Protein name | ZDHC8 |
| Human gene link | View Human Gene |
| Human Swiss link | View Human Swiss-Prot |
| Mouse gene ID | 27801 |
| Mouse gene link | View Mouse Gene |
| Mouse Swiss-Prot | Q5Y5T5 |
| Mouse Swiss link | View Mouse Swiss-Prot |
| Rat gene ID | |
| Rat gene link | |
| Rat Swiss-Prot | |
| Rat Swiss link | |
| Immunogen | Synthesized peptide derived from human ZDHC8 AA range: 289-339 |
| Specificity | This antibody detects endogenous levels of ZDHC8 at Human/Mouse |
| Formulation | Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.310% sodium azide. |
| Clonality | Polyclonal |
| Dilution | WB 1:500-2000 |
| Purification | The antibody was affinity-purified from rabbit serum by affinity-chromatography using specific immunogen. |
| Concentration | 1 mg/ml |
| Storage stability | -20°C/1 year |
| Molecular Weight (Da) | |
| Observed band (KD) | 85kD |
| Background | This gene encodes a four transmembrane protein that is a member of the zinc finger DHHC domain-containing protein family. The encoded protein may function as a palmitoyltransferase. Defects in this gene may be associated with a susceptibility to schizophrenia. Alternate splicing of this gene results in multiple transcript variants. A pseudogene of this gene is found on chromosome 22.[provided by RefSeq, May 2010], |
| Function | catalytic activity:Palmitoyl-CoA + protein-cysteine = S-palmitoyl protein + CoA.,disease:According to PubMed:15489219 and PubMed:15184899, defects in ZDHHC8 may contribute to susceptibility to schizophrenia, but according to PubMed:15992527, PubMed:15631889 and PubMed:16150541, it is not the case.,domain:The DHHC domain is required for palmitoyltransferase activity.,function:Putative palmitoyltransferase involved in glutamatergic transmission.,similarity:Belongs to the DHHC palmitoyltransferase family. ERF2/ZDHHC9 subfamily.,similarity:Contains 1 DHHC-type zinc finger., |
| Subcellular location | Golgi apparatus membrane ; Multi-pass membrane protein . Mitochondrion membrane ; Multi-pass membrane protein . |
| Expression | Widely expressed. |
Additional Images
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Western blot analysis of lysates from A549 cells, primary antibody was diluted at 1:1000, 4°over night
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: AO-06-ES12217-100
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