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Antibody Product Overview
| ELK.No | ES12257 |
| Product name | YMEL1 rabbit pAb |
| Reactivity | Human; Mouse;Rat |
| Applications | WB |
| Other name | ATP-dependent zinc metalloprotease YME1L1 (EC 3.4.24.-) (ATP-dependent metalloprotease FtsH1) (Meg-4) (Presenilin-associated metalloprotease) (PAMP) (YME1-like protein 1) |
| Size | 100μL |
| Unit price ($) | 248 |
| Human gene ID | 10730 |
| Human Swiss-Prot | Q96TA2 |
| Source | Rabbit |
| Isotype | IgG |
| Target | YMEL1 |
| Fields | |
| Gene name | YME1L1 FTSH1 YME1L UNQ1868/PRO4304 |
| Protein name | YMEL1 |
| Human gene link | View Human Gene |
| Human Swiss link | View Human Swiss-Prot |
| Mouse gene ID | 27377 |
| Mouse gene link | View Mouse Gene |
| Mouse Swiss-Prot | O88967 |
| Mouse Swiss link | View Mouse Swiss-Prot |
| Rat gene ID | |
| Rat gene link | |
| Rat Swiss-Prot | Q925S8 |
| Rat Swiss link | View Rat Swiss-Prot |
| Immunogen | Synthesized peptide derived from human YMEL1 AA range: 136-186 |
| Specificity | This antibody detects endogenous levels of YMEL1 at Human/Mouse/Rat |
| Formulation | Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.353% sodium azide. |
| Clonality | Polyclonal |
| Dilution | WB 1:500-2000 |
| Purification | The antibody was affinity-purified from rabbit serum by affinity-chromatography using specific immunogen. |
| Concentration | 1 mg/ml |
| Storage stability | -20°C/1 year |
| Molecular Weight (Da) | |
| Observed band (KD) | 85kD |
| Background | The protein encoded by this gene is the human ortholog of yeast mitochondrial AAA metalloprotease, Yme1p. It is localized in the mitochondria and can functionally complement a yme1 disruptant yeast strain. It is proposed that this gene plays a role in mitochondrial protein metabolism and could be involved in mitochondrial pathologies. Three transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Dec 2011], |
| Function | cofactor:Binds 1 zinc ion per subunit .,function:Putative ATP-dependent protease which plays a role in mitochondrial protein metabolism.,similarity:In the C-terminal section; belongs to the peptidase M41 family.,similarity:In the N-terminal section; belongs to the AAA ATPase family., |
| Subcellular location | Mitochondrion inner membrane . Mitochondrion . |
| Expression | High expression in cardiac and skeletal muscle mitochondria. |
Additional Images
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Western blot analysis of lysates from A549 cells, primary antibody was diluted at 1:1000, 4°over night
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: AO-06-ES12257-100
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