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Antibody Product Overview
| ELK.No | ES12272 |
| Product name | XYLT1 rabbit pAb |
| Reactivity | Human; Mouse;Rat |
| Applications | WB |
| Other name | Xylosyltransferase 1 (EC 2.4.2.26) (Peptide O-xylosyltransferase 1) (Xylosyltransferase I) (XT-I) (XylT-I) |
| Size | 100μL |
| Unit price ($) | 248 |
| Human gene ID | 64131 |
| Human Swiss-Prot | Q86Y38 |
| Source | Rabbit |
| Isotype | IgG |
| Target | XYLT1 |
| Fields | >>Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate;>>Glycosaminoglycan biosynthesis - heparan sulfate / heparin;>>Metabolic pathways |
| Gene name | XYLT1 XT1 |
| Protein name | XYLT1 |
| Human gene link | View Human Gene |
| Human Swiss link | View Human Swiss-Prot |
| Mouse gene ID | 233781 |
| Mouse gene link | View Mouse Gene |
| Mouse Swiss-Prot | Q811B1 |
| Mouse Swiss link | View Mouse Swiss-Prot |
| Rat gene ID | |
| Rat gene link | |
| Rat Swiss-Prot | Q9EPI1 |
| Rat Swiss link | View Rat Swiss-Prot |
| Immunogen | Synthesized peptide derived from human XYLT1 AA range: 312-362 |
| Specificity | This antibody detects endogenous levels of XYLT1 at Human/Mouse/Rat |
| Formulation | Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.253% sodium azide. |
| Clonality | Polyclonal |
| Dilution | WB 1:500-2000 |
| Purification | The antibody was affinity-purified from rabbit serum by affinity-chromatography using specific immunogen. |
| Concentration | 1 mg/ml |
| Storage stability | -20°C/1 year |
| Molecular Weight (Da) | |
| Observed band (KD) | 105kD |
| Background | This locus encodes a xylosyltransferase enzyme. The encoded protein catalyzes transfer of UDP-xylose to serine residues of an acceptor protein substrate. This transfer reaction is necessary for biosynthesis of glycosaminoglycan chains. Mutations in this gene have been associated with increased severity of pseudoxanthoma elasticum.[provided by RefSeq, Nov 2009], |
| Function | catalytic activity:Transfers a beta-D-xylosyl residue from UDP-D-xylose to the serine hydroxy group of an acceptor protein substrate.,cofactor:Divalent cations.,function:Catalyzes the first step in biosynthesis of glycosaminoglycan. Transfers D-xylose from UDP-D-xylose to specific serine residues of the core protein. Initial enzyme in the biosynthesis of chondroitin sulfate and dermatan sulfate proteoglycans in fibroblasts and chondrocytes.,miscellaneous:Activity is strongly reduced in seminal plasma of unfertile men.,online information:GlycoGene database,pathway:Glycan metabolism; chondroitin sulfate biosynthesis.,pathway:Glycan metabolism; heparan sulfate biosynthesis.,PTM:Contains 7 disulfide bonds.,PTM:N-glycosylated.,similarity:Belongs to the glycosyltransferase 14 family. XylT subfamily.,subcellular location:Some fraction is also found in the extracellular space together with chond |
| Subcellular location | Golgi apparatus membrane ; Single-pass type II membrane protein . Secreted . Detected predominantly in the Golgi apparatus. . |
| Expression | Widely expressed. Expressed at higher level in placenta, kidney and pancreas. Weakly expressed in skeletal muscle. |
Additional Images
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Western blot analysis of lysates from SW480 cells, primary antibody was diluted at 1:1000, 4°over night
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: AO-06-ES12272-100
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