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Antibody Product Overview
| ELK.No | ES12347 |
| Product name | VPS45 rabbit pAb |
| Reactivity | Human; Mouse;Rat |
| Applications | WB |
| Other name | Vacuolar protein sorting-associated protein 45 (h-VPS45) (hlVps45) |
| Size | 100μL |
| Unit price ($) | 248 |
| Human gene ID | 11311 |
| Human Swiss-Prot | Q9NRW7 |
| Source | Rabbit |
| Isotype | IgG |
| Target | VPS45 |
| Fields | >>Endocytosis |
| Gene name | VPS45 VPS45A VPS45B |
| Protein name | VPS45 |
| Human gene link | View Human Gene |
| Human Swiss link | View Human Swiss-Prot |
| Mouse gene ID | 22365 |
| Mouse gene link | View Mouse Gene |
| Mouse Swiss-Prot | P97390 |
| Mouse Swiss link | View Mouse Swiss-Prot |
| Rat gene ID | 64516 |
| Rat gene link | View Rat Gene |
| Rat Swiss-Prot | O08700 |
| Rat Swiss link | View Rat Swiss-Prot |
| Immunogen | Synthesized peptide derived from human VPS45 AA range: 470-520 |
| Specificity | This antibody detects endogenous levels of VPS45 at Human/Mouse/Rat |
| Formulation | Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.188% sodium azide. |
| Clonality | Polyclonal |
| Dilution | WB 1:500-2000 |
| Purification | The antibody was affinity-purified from rabbit serum by affinity-chromatography using specific immunogen. |
| Concentration | 1 mg/ml |
| Storage stability | -20°C/1 year |
| Molecular Weight (Da) | |
| Observed band (KD) | 65kD |
| Background | Vesicle mediated protein sorting plays an important role in segregation of intracellular molecules into distinct organelles. Genetic studies in yeast have identified more than 40 vacuolar protein sorting (VPS) genes involved in vesicle transport to vacuoles. This gene is a member of the Sec1 domain family, and shows a high degree of sequence similarity to mouse, rat and yeast Vps45. The exact function of this gene is not known, but its high expression in peripheral blood mononuclear cells suggests a role in trafficking proteins, including inflammatory mediators. Multiple alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Jul 2013], |
| Function | function:May play a role in vesicle-mediated protein trafficking from the Golgi stack through the trans-Golgi network.,similarity:Belongs to the STXBP/unc-18/SEC1 family.,subcellular location:Associated with Golgi/endosomal vesicles and the trans-Golgi network.,subunit:Interacts with STX6 (By similarity). Interacts with ZFYVE20.,tissue specificity:Ubiquitous. Expression was highest in testis, heart and brain, intermediate in kidney, spleen, prostate, ovary, small intestine and thymus and low in lung, skeletal muscle, placenta, colon, pancreas, peripheral blood leukocytes and liver., |
| Subcellular location | Golgi apparatus membrane ; Peripheral membrane protein . Endosome membrane ; Peripheral membrane protein . Associated with Golgi/endosomal vesicles and the trans-Golgi network. . |
| Expression | Ubiquitous. Expression was highest in testis, heart and brain, intermediate in kidney, spleen, prostate, ovary, small intestine and thymus and low in lung, skeletal muscle, placenta, colon, pancreas, peripheral blood leukocytes and liver. |
Additional Images
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Western blot analysis of lysates from HpeG2 cells, primary antibody was diluted at 1:1000, 4°over night
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: AO-06-ES12347-100
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