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Antibody Product Overview
| ELK.No | ES12352 |
| Product name | VP33B rabbit pAb |
| Reactivity | Human; Mouse;Rat |
| Applications | WB |
| Other name | |
| Size | 50μL |
| Unit price ($) | 148 |
| Human gene ID | 26276 |
| Human Swiss-Prot | Q9H267 |
| Source | Rabbit |
| Isotype | IgG |
| Target | VP33B |
| Fields | |
| Gene name | VPS33B |
| Protein name | VP33B |
| Human gene link | View Human Gene |
| Human Swiss link | View Human Swiss-Prot |
| Mouse gene ID | 233405 |
| Mouse gene link | View Mouse Gene |
| Mouse Swiss-Prot | P59016 |
| Mouse Swiss link | View Mouse Swiss-Prot |
| Rat gene ID | 64060 |
| Rat gene link | View Rat Gene |
| Rat Swiss-Prot | Q63616 |
| Rat Swiss link | View Rat Swiss-Prot |
| Immunogen | Synthesized peptide derived from human VP33B AA range: 12-62 |
| Specificity | This antibody detects endogenous levels of VP33B at Human/Mouse/Rat |
| Formulation | Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide. |
| Clonality | Polyclonal |
| Dilution | WB 1：500-2000 |
| Purification | The antibody was affinity-purified from rabbit serum by affinity-chromatography using specific immunogen. |
| Concentration | 1 mg/ml |
| Storage stability | -20°C/1 year |
| Molecular Weight (Da) | 68kD |
| Observed band (KD) | |
| Background | Vesicle mediated protein sorting plays an important role in segregation of intracellular molecules into distinct organelles. Genetic studies in yeast have identified more than 40 vacuolar protein sorting (VPS) genes involved in vesicle transport to vacuoles. This gene is a member of the Sec-1 domain family, and encodes the human ortholog of rat Vps33b which is homologous to the yeast class C Vps33 protein. The mammalian class C vacuolar protein sorting proteins are predominantly associated with late endosomes/lysosomes, and like their yeast counterparts, may mediate vesicle trafficking steps in the endosome/lysosome pathway. Mutations in this gene are associated with arthrogryposis-renal dysfunction-cholestasis syndrome. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jan 2014], |
| Function | disease:Defects in VPS33B are the cause of arthrogryposis-renal dysfunction-cholestasis syndrome (ARC) [MIM:208085]. ARC is an autosomal recessive multisystem disorder, characterized by neurogenic arthrogryposis multiplex congenita, renal tubular dysfunction and neonatal cholestasis with bile duct hypoplasia and low gamma glutamyl transpeptidase activity. Platelet dysfunction is common.,function:May play a role in vesicle-mediated protein trafficking to lysosomal compartments and in membrane docking/fusion reactions of late endosomes/lysosomes.,similarity:Belongs to the STXBP/unc-18/SEC1 family.,subcellular location:Cytoplasmic, peripheral membrane protein associated with late endosomes/lysosomes.,tissue specificity:Ubiquitous; highly expressed in testis and low expression in the lung., |
| Subcellular location | Late endosome membrane ; Peripheral membrane protein; Cytoplasmic side. Lysosome membrane ; Peripheral membrane protein; Cytoplasmic side. Early endosome . Cytoplasmic vesicle, clathrin-coated vesicle . Recycling endosome . Colocalizes in clusters with VIPAS39 at cytoplasmic organelles (PubMed:19109425). Colocalizes with RAB11A and VIPAS39 on recycling endosomes (PubMed:22753090). Colocalizes with AP-3, clathrin, Rab5 and Rab7b (PubMed:21411634). Colocalizes with M.tuberculosis PtpA in the cytosol of tuberculosis-infected macrophages and associates with phagosomes (PubMed:18474358). . |
| Expression | Ubiquitous; highly expressed in testis and low expression in the lung. |
Additional Images
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Western blot analysis of lysates from MCF-7 cells, primary antibody was diluted at 1:1000, 4°over night
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: AO-06-ES12352-50
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