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ULK1 (phospho-Ser757) rabbit pAb
AO-06-ES12425-50
Antibody Product Overview
| ELK.No | ES12425 |
| Product name | ULK1 (phospho-Ser757) rabbit pAb |
| Reactivity | Human;Mouse;Rat |
| Applications | WB |
| Other name | Serine/threonine-protein kinase ULK1 (EC 2.7.11.1) (Autophagy-related protein 1 homolog) (ATG1) (hATG1) (Unc-51-like kinase 1) |
| Size | 50μL |
| Unit price ($) | 148 |
| Human gene ID | 8408 |
| Human Swiss-Prot | O75385 |
| Source | Rabbit |
| Isotype | IgG |
| Target | ULK1 |
| Fields | >>Mitophagy - animal;>>Autophagy - animal;>>mTOR signaling pathway;>>AMPK signaling pathway;>>Longevity regulating pathway;>>Alzheimer disease;>>Amyotrophic lateral sclerosis;>>Huntington disease;>>Spinocerebellar ataxia;>>Pathways of neurodegeneration - multiple diseases |
| Gene name | ULK1 KIAA0722 |
| Protein name | ULK1 (Ser757) |
| Human gene link | View Human Gene |
| Human Swiss link | View Human Swiss-Prot |
| Mouse gene ID | 22241 |
| Mouse gene link | View Mouse Gene |
| Mouse Swiss-Prot | O70405 |
| Mouse Swiss link | View Mouse Swiss-Prot |
| Rat gene ID | |
| Rat gene link | |
| Rat Swiss-Prot | |
| Rat Swiss link | |
| Immunogen | Synthesized phosho peptide around human ULK1 (Ser757) |
| Specificity | This antibody detects endogenous levels of Human Mouse Rat ULK1 (phospho-Ser757) |
| Formulation | Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide. |
| Clonality | Polyclonal |
| Dilution | WB 1:1000-2000 |
| Purification | The antibody was affinity-purified from rabbit serum by affinity-chromatography using specific immunogen. |
| Concentration | 1 mg/ml |
| Storage stability | -20°C/1 year |
| Molecular Weight (Da) | |
| Observed band (KD) | 115kD |
| Background | |
| Function | catalytic activity:ATP + a protein = ADP + a phosphoprotein.,function:Involved in axon growth. Plays an essential role in neurite extension of cerebellar granule cells.,similarity:Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. APG1/unc-51/ULK1 subfamily.,similarity:Contains 1 protein kinase domain.,subunit:Interacts with GABARAP and GABARAPL2.,tissue specificity:Ubiquitously expressed. Detected in the following adult tissues: skeletal muscle, heart, pancreas, brain, placenta, liver, kidney, and lung., |
| Subcellular location | Cytoplasm, cytosol . Preautophagosomal structure . Under starvation conditions, is localized to puncate structures primarily representing the isolation membrane that sequesters a portion of the cytoplasm resulting in the formation of an autophagosome. . |
| Expression | Ubiquitously expressed. Detected in the following adult tissues: skeletal muscle, heart, pancreas, brain, placenta, liver, kidney, and lung. |
Additional Images
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Western Blot analysis of various cell lysis(provided by our customer). Primary Antibody was diluted at 1:1000. Secondary antibody(catalog#:RS23920 was diluted at 1:10000
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: AO-06-ES12425-50
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