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Antibody Product Overview
| ELK.No | ES12453 |
| Product name | UBE2B rabbit pAb |
| Reactivity | Human; Mouse;Rat |
| Applications | WB |
| Other name | |
| Size | 100μL |
| Unit price ($) | 248 |
| Human gene ID | 7320 |
| Human Swiss-Prot | P63146 |
| Source | Rabbit |
| Isotype | IgG |
| Target | UBE2B |
| Fields | >>Ubiquitin mediated proteolysis |
| Gene name | UBE2B RAD6B |
| Protein name | UBE2B |
| Human gene link | View Human Gene |
| Human Swiss link | View Human Swiss-Prot |
| Mouse gene ID | 22210 |
| Mouse gene link | View Mouse Gene |
| Mouse Swiss-Prot | P63147 |
| Mouse Swiss link | View Mouse Swiss-Prot |
| Rat gene ID | 81816 |
| Rat gene link | View Rat Gene |
| Rat Swiss-Prot | P63149 |
| Rat Swiss link | View Rat Swiss-Prot |
| Immunogen | Synthesized peptide derived from human UBE2B AA range: 23-73 |
| Specificity | This antibody detects endogenous levels of UBE2B at Human/Mouse/Rat |
| Formulation | Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide. |
| Clonality | Polyclonal |
| Dilution | WB 1：500-2000 |
| Purification | The antibody was affinity-purified from rabbit serum by affinity-chromatography using specific immunogen. |
| Concentration | 1 mg/ml |
| Storage stability | -20°C/1 year |
| Molecular Weight (Da) | 17kD |
| Observed band (KD) | |
| Background | The modification of proteins with ubiquitin is an important cellular mechanism for targeting abnormal or short-lived proteins for degradation. Ubiquitination involves at least three classes of enzymes: ubiquitin-activating enzymes, or E1s, ubiquitin-conjugating enzymes, or E2s, and ubiquitin-protein ligases, or E3s. This gene encodes a member of the E2 ubiquitin-conjugating enzyme family. This enzyme is required for post-replicative DNA damage repair. Its protein sequence is 100% identical to the mouse, rat, and rabbit homologs, which indicates that this enzyme is highly conserved in eukaryotic evolution. [provided by RefSeq, Jul 2008], |
| Function | catalytic activity:ATP + ubiquitin + protein lysine = AMP + diphosphate + protein N-ubiquityllysine.,function:Catalyzes the covalent attachment of ubiquitin to other proteins. Required for postreplication repair of UV-damaged DNA. Associates to the E3 ligase RAD18 to form the UBE2B-RAD18 ubiquitin ligase complex involved in mono-ubiquitination of DNA-associated PCNA on 'Lys-164'. May be involved in neurite outgrowth.,pathway:Protein modification; protein ubiquitination.,similarity:Belongs to the ubiquitin-conjugating enzyme family.,subcellular location:In peripheral neurons, expressed both at the plasma membrane and in nuclei.,subunit:Interacts with RAD18 and UBR2., |
| Subcellular location | Cell membrane . Nucleus . In peripheral neurons, expressed both at the plasma membrane and in nuclei. . |
| Expression |
Additional Images
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Western blot analysis of lysates from A549 cells, primary antibody was diluted at 1:1000, 4°over night
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: AO-06-ES12453-100
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