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Antibody Product Overview
| ELK.No | ES12465 |
| Product name | TYW2 rabbit pAb |
| Reactivity | Human; Mouse;Rat |
| Applications | WB |
| Other name | |
| Size | 50μL |
| Unit price ($) | 148 |
| Human gene ID | 55039 |
| Human Swiss-Prot | Q53H54 |
| Source | Rabbit |
| Isotype | IgG |
| Target | TYW2 |
| Fields | |
| Gene name | TRMT12 TRM12 TYW2 |
| Protein name | TYW2 |
| Human gene link | View Human Gene |
| Human Swiss link | View Human Swiss-Prot |
| Mouse gene ID | 68260 |
| Mouse gene link | View Mouse Gene |
| Mouse Swiss-Prot | Q8BG71 |
| Mouse Swiss link | View Mouse Swiss-Prot |
| Rat gene ID | 314999 |
| Rat gene link | View Rat Gene |
| Rat Swiss-Prot | Q4V8B8 |
| Rat Swiss link | View Rat Swiss-Prot |
| Immunogen | Synthesized peptide derived from human TYW2 AA range: 11-61 |
| Specificity | This antibody detects endogenous levels of TYW2 at Human/Mouse/Rat |
| Formulation | Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide. |
| Clonality | Polyclonal |
| Dilution | WB 1：500-2000 |
| Purification | The antibody was affinity-purified from rabbit serum by affinity-chromatography using specific immunogen. |
| Concentration | 1 mg/ml |
| Storage stability | -20°C/1 year |
| Molecular Weight (Da) | 49kD |
| Observed band (KD) | |
| Background | Wybutosine (yW) is a hypermodified guanosine at the 3-prime position adjacent to the anticodon of phenylalanine tRNA that stabilizes codon-anticodon interactions during decoding on the ribosome. TRMT12 is the human homolog of a yeast gene essential for yW synthesis (Noma and Suzuki, 2006).[supplied by OMIM, Mar 2008], |
| Function | function:Probable S-adenosyl-L-methionine-dependent methyltransferase that acts as a component of the wybutosine biosynthesis pathway. Wybutosine is a hyper modified guanosine with a tricyclic base found at the 3'-position adjacent to the anticodon of eukaryotic phenylalanine tRNA.,pathway:tRNA modification; wybutosine-tRNA(Phe) biosynthesis.,sequence caution:Contaminating sequence. Potential poly-A sequence starting in position 371.,sequence caution:Translation N-terminally shortened.,similarity:Belongs to the RNA methyltransferase trmD family. TYW2 subfamily., |
| Subcellular location | |
| Expression |
Additional Images
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Western blot analysis of lysates from Hela cells, primary antibody was diluted at 1:1000, 4°over night
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: AO-06-ES12465-50
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