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Antibody Product Overview
| ELK.No | ES12521 |
| Product name | TTC5 rabbit pAb |
| Reactivity | Human; Mouse;Rat |
| Applications | WB |
| Other name | |
| Size | 50μL |
| Unit price ($) | 148 |
| Human gene ID | 91875 |
| Human Swiss-Prot | Q8N0Z6 |
| Source | Rabbit |
| Isotype | IgG |
| Target | TTC5 |
| Fields | |
| Gene name | TTC5 |
| Protein name | TTC5 |
| Human gene link | View Human Gene |
| Human Swiss link | View Human Swiss-Prot |
| Mouse gene ID | 219022 |
| Mouse gene link | View Mouse Gene |
| Mouse Swiss-Prot | Q99LG4 |
| Mouse Swiss link | View Mouse Swiss-Prot |
| Rat gene ID | 305837 |
| Rat gene link | View Rat Gene |
| Rat Swiss-Prot | Q5BK48 |
| Rat Swiss link | View Rat Swiss-Prot |
| Immunogen | Synthesized peptide derived from human TTC5 AA range: 82-132 |
| Specificity | This antibody detects endogenous levels of TTC5 at Human/Mouse/Rat |
| Formulation | Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide. |
| Clonality | Polyclonal |
| Dilution | WB 1：500-2000 |
| Purification | The antibody was affinity-purified from rabbit serum by affinity-chromatography using specific immunogen. |
| Concentration | 1 mg/ml |
| Storage stability | -20°C/1 year |
| Molecular Weight (Da) | 48kD |
| Observed band (KD) | |
| Background | |
| Function | function:Adapter protein involved in p53/TP53 response that acts by regulating and mediating the assembly of multi-protein complexes. Required to facilitate the interaction between JMY and p300/EP300 and increase p53/TP53-dependent transcription and apoptosis. Prevents p53/TP53 degradation by MDM2.,PTM:Phosphorylation at Ser-203 enhances protein stability, regulates nuclear accumulation and association with p300/EP300.,similarity:Contains 4 TPR repeats.,subcellular location:Phosphorylation at Ser-203 results in nuclear localization, while unphosphorylated protein localizes to the cytoplasm.,subunit:Interacts with JMY and p300/EP300., |
| Subcellular location | Nucleus . Cytoplasm . Cytoplasmic vesicle . Mitochondrion matrix . Phosphorylation at Ser-203 results in nuclear localization, while unphosphorylated protein localizes to the cytoplasm. Nuclear localization may be necessary for DNA damage-dependent stabilization of the protein. . |
| Expression |
Additional Images
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Western blot analysis of lysates from A431 cells, primary antibody was diluted at 1:1000, 4°over night
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: AO-06-ES12521-50
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