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Antibody Product Overview
| ELK.No | ES12545 |
| Product name | TRPM4 rabbit pAb |
| Reactivity | Human; Mouse;Rat |
| Applications | WB |
| Other name | |
| Size | 50μL |
| Unit price ($) | 148 |
| Human gene ID | 54795 |
| Human Swiss-Prot | Q8TD43 |
| Source | Rabbit |
| Isotype | IgG |
| Target | TRPM4 |
| Fields | >>Insulin secretion |
| Gene name | TRPM4 LTRPC4 |
| Protein name | TRPM4 |
| Human gene link | View Human Gene |
| Human Swiss link | View Human Swiss-Prot |
| Mouse gene ID | 68667 |
| Mouse gene link | View Mouse Gene |
| Mouse Swiss-Prot | Q7TN37 |
| Mouse Swiss link | View Mouse Swiss-Prot |
| Rat gene ID | 171143 |
| Rat gene link | View Rat Gene |
| Rat Swiss-Prot | Q9ESQ5 |
| Rat Swiss link | View Rat Swiss-Prot |
| Immunogen | Synthesized peptide derived from human TRPM4 AA range: 1089-1139 |
| Specificity | This antibody detects endogenous levels of TRPM4 at Human/Mouse/Rat |
| Formulation | Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide. |
| Clonality | Polyclonal |
| Dilution | WB 1：500-2000 |
| Purification | The antibody was affinity-purified from rabbit serum by affinity-chromatography using specific immunogen. |
| Concentration | 1 mg/ml |
| Storage stability | -20°C/1 year |
| Molecular Weight (Da) | 134kD |
| Observed band (KD) | |
| Background | The protein encoded by this gene is a calcium-activated nonselective ion channel that mediates transport of monovalent cations across membranes, thereby depolarizing the membrane. The activity of the encoded protein increases with increasing intracellular calcium concentration, but this channel does not transport calcium. [provided by RefSeq, Mar 2016], |
| Function | enzyme regulation:Gating is voltage-dependent and repressed by decavanadate. Calmodulin-binding confers the Ca(2+) sensitivity. ATP is able to restore Ca(2+) sensitivity after desensitization. Phosphatidylinositol 4,5-biphosphate (PIP2)-binding strongly enhances activity, by increasing the channel's Ca(2+) sensitivity and shifting its voltage dependence of activation towards negative potentials. Activity is also enhanced by 3,5-bis(trifluoromethyl)pyrazole derivative (BTP2).,function:Calcium-activated non selective (CAN) cation channel that mediates membrane depolarization. While it is activated by increase in intracellular Ca(2+), it is impermeable to it. Mediates transport of monovalent cations (Na(+) > K(+) > Cs(+) > Li(+)), leading to depolarize the membrane. It thereby plays a central role in cadiomyocytes, neurons from entorhinal cortex, dorsal root and vomeronasal neurons, endocri |
| Subcellular location | [Isoform 1]: Cell membrane ; Multi-pass membrane protein . Endoplasmic reticulum . Golgi apparatus .; [Isoform 2]: Cell membrane . Endoplasmic reticulum. Golgi apparatus. |
| Expression | Widely expressed with a high expression in intestine and prostate. In brain, it is both expressed in whole cerebral arteries and isolated vascular smooth muscle cells. Prominently expressed in Purkinje fibers. Expressed at higher levels in T-helper 2 (Th2) cells as compared to T-helper 1 (Th1) cells. Expressed in keratocytes (PubMed:30528822). |
Additional Images
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Western blot analysis of lysates from HpeG2 cells, primary antibody was diluted at 1:1000, 4°over night
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: AO-06-ES12545-50
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