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Antibody Product Overview
| ELK.No | ES12885 |
| Product name | STXB2 rabbit pAb |
| Reactivity | Human; Mouse;Rat |
| Applications | WB;ELISA;IHC |
| Other name | |
| Size | 100μL |
| Unit price ($) | 248 |
| Human gene ID | 6813 |
| Human Swiss-Prot | Q15833 |
| Source | Rabbit |
| Isotype | IgG |
| Target | STXB2 |
| Fields | |
| Gene name | STXBP2 UNC18B |
| Protein name | STXB2 |
| Human gene link | View Human Gene |
| Human Swiss link | View Human Swiss-Prot |
| Mouse gene ID | 20911 |
| Mouse gene link | View Mouse Gene |
| Mouse Swiss-Prot | Q64324 |
| Mouse Swiss link | View Mouse Swiss-Prot |
| Rat gene ID | 81804 |
| Rat gene link | View Rat Gene |
| Rat Swiss-Prot | Q62753 |
| Rat Swiss link | View Rat Swiss-Prot |
| Immunogen | Synthesized peptide derived from human STXB2 AA range: 392-442 |
| Specificity | This antibody detects endogenous levels of STXB2 at Human/Mouse/Rat |
| Formulation | Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide. |
| Clonality | Polyclonal |
| Dilution | WB 1:500-2000;IHC-p 1:50-300; ELISA 2000-20000 |
| Purification | The antibody was affinity-purified from rabbit serum by affinity-chromatography using specific immunogen. |
| Concentration | 1 mg/ml |
| Storage stability | -20°C/1 year |
| Molecular Weight (Da) | 65kD |
| Observed band (KD) | |
| Background | This gene encodes a member of the STXBP/unc-18/SEC1 family. The encoded protein is involved in intracellular trafficking, control of SNARE (soluble NSF attachment protein receptor) complex assembly, and the release of cytotoxic granules by natural killer cells. Mutations in this gene are associated with familial hemophagocytic lymphohistiocytosis. Alternatively spliced transcript variants encoding different isoforms have been noted for this gene. [provided by RefSeq, Jan 2013], |
| Function | function:Involved in the protein trafficking from the Golgi apparatus to the plasma membrane.,similarity:Belongs to the STXBP/unc-18/SEC1 family.,subunit:Binds syntaxins 1A, 2, 3 but not 4.,tissue specificity:Placenta, lung, liver, kidney and pancreas, as well as in peripheral blood lymphocytes., |
| Subcellular location | cytosol,plasma membrane,integral component of membrane,apical plasma membrane,SNARE complex,specific granule,azurophil granule,zymogen granule membrane,cytolytic granule,extracellular exosome,tertiary granule, |
| Expression | Placenta, lung, liver, kidney and pancreas, as well as in peripheral blood lymphocytes. |
Additional Images
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Western blot analysis of lysates from AD293 cells, primary antibody was diluted at 1:1000, 4°over night
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Immunohistochemical analysis of paraffin-embedded human oophoroma. 1, Antibody was diluted at 1:200(4° overnight). 2, Tris-EDTA,pH9.0 was used for antigen retrieval. 3,Secondary antibody was diluted at 1:200(room temperature, 45min).
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: AO-06-ES12885-100
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