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Antibody Product Overview
| ELK.No | ES12886 |
| Product name | STX8 rabbit pAb |
| Reactivity | Human; Mouse;Rat |
| Applications | WB;ELISA;IHC |
| Other name | |
| Size | 100μL |
| Unit price ($) | 248 |
| Human gene ID | 9482 |
| Human Swiss-Prot | Q9UNK0 |
| Source | Rabbit |
| Isotype | IgG |
| Target | STX8 |
| Fields | >>SNARE interactions in vesicular transport |
| Gene name | STX8 |
| Protein name | STX8 |
| Human gene link | View Human Gene |
| Human Swiss link | View Human Swiss-Prot |
| Mouse gene ID | 55943 |
| Mouse gene link | View Mouse Gene |
| Mouse Swiss-Prot | O88983 |
| Mouse Swiss link | View Mouse Swiss-Prot |
| Rat gene ID | 59074 |
| Rat gene link | View Rat Gene |
| Rat Swiss-Prot | Q9Z2Q7 |
| Rat Swiss link | View Rat Swiss-Prot |
| Immunogen | Synthesized peptide derived from human STX8 AA range: 42-92 |
| Specificity | This antibody detects endogenous levels of STX8 at Human/Mouse/Rat |
| Formulation | Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide. |
| Clonality | Polyclonal |
| Dilution | WB 1:500-2000;IHC-p 1:50-300; ELISA 2000-20000 |
| Purification | The antibody was affinity-purified from rabbit serum by affinity-chromatography using specific immunogen. |
| Concentration | 1 mg/ml |
| Storage stability | -20°C/1 year |
| Molecular Weight (Da) | 26kD |
| Observed band (KD) | |
| Background | The gene is a member of the syntaxin family. The encoded protein is involved in protein trafficking from early to late endosomes via vesicle fusion and exocytosis. A related pseudogene has been identified on chromosome 12. Alternative splicing results in multiple transcript variants. [provided by RefSeq, May 2010], |
| Function | function:Vesicle trafficking protein that functions in the early secretory pathway, possibly by mediating retrograde transport from cis-Golgi membranes to the ER.,similarity:Belongs to the syntaxin family.,similarity:Contains 1 t-SNARE coiled-coil homology domain.,subcellular location:Preferentially associated with the early endosome. To lesser extends, also present in late endosome, the plasma membrane and coated pits.,subunit:Forms a SNARE complex with STX7, VTI1B and VAMP8 which functions in the homotypic fusion of late endosomes. Part of the SNARE core complex containing STX7, VAMP8 and VTI1B. Interacts with VAMP8.,tissue specificity:Highly expressed in heart. Also found in brain, kidney, liver, lung, placenta, skeletal muscle, spleen and pancreas., |
| Subcellular location | Membrane ; Single-pass type IV membrane protein . Preferentially associated with the early endosome. To a lesser extent, also present in late endosome, the plasma membrane and coated pits (By similarity). . |
| Expression | Highly expressed in heart. Also found in brain, kidney, liver, lung, placenta, skeletal muscle, spleen and pancreas. |
Additional Images
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Western blot analysis of lysates from HpeG2 cells, primary antibody was diluted at 1:1000, 4°over night
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Immunohistochemical analysis of paraffin-embedded human liver cancer. 1, Antibody was diluted at 1:200(4° overnight). 2, Tris-EDTA,pH9.0 was used for antigen retrieval. 3,Secondary antibody was diluted at 1:200(room temperature, 45min).
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: AO-06-ES12886-100
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