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Antibody Product Overview
| ELK.No | ES12972 |
| Product name | SPTC2 rabbit pAb |
| Reactivity | Human; Mouse |
| Applications | WB |
| Other name | Serine palmitoyltransferase 2 (EC 2.3.1.50) (Long chain base biosynthesis protein 2) (LCB 2) (Long chain base biosynthesis protein 2a) (LCB2a) (Serine-palmitoyl-CoA transferase 2) (SPT 2) |
| Size | 50μL |
| Unit price ($) | 148 |
| Human gene ID | 9517 |
| Human Swiss-Prot | O15270 |
| Source | Rabbit |
| Isotype | IgG |
| Target | SPTC2 |
| Fields | >>Sphingolipid metabolism;>>Metabolic pathways;>>Sphingolipid signaling pathway |
| Gene name | SPTLC2 KIAA0526 LCB2 |
| Protein name | SPTC2 |
| Human gene link | View Human Gene |
| Human Swiss link | View Human Swiss-Prot |
| Mouse gene ID | 20773 |
| Mouse gene link | View Mouse Gene |
| Mouse Swiss-Prot | P97363 |
| Mouse Swiss link | View Mouse Swiss-Prot |
| Rat gene ID | |
| Rat gene link | |
| Rat Swiss-Prot | |
| Rat Swiss link | |
| Immunogen | Synthesized peptide derived from human SPTC2 AA range: 273-323 |
| Specificity | This antibody detects endogenous levels of SPTC2 at Human/Mouse |
| Formulation | Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.100% sodium azide. |
| Clonality | Polyclonal |
| Dilution | WB 1:500-2000 |
| Purification | The antibody was affinity-purified from rabbit serum by affinity-chromatography using specific immunogen. |
| Concentration | 1 mg/ml |
| Storage stability | -20°C/1 year |
| Molecular Weight (Da) | |
| Observed band (KD) | 60kD |
| Background | This gene encodes a long chain base subunit of serine palmitoyltransferase. Serine palmitoyltransferase, which consists of two different subunits, is the key enzyme in sphingolipid biosynthesis. It catalyzes the pyridoxal-5-prime-phosphate-dependent condensation of L-serine and palmitoyl-CoA to 3-oxosphinganine. Mutations in this gene were identified in patients with hereditary sensory neuropathy type I. [provided by RefSeq, Mar 2011], |
| Function | catalytic activity:Palmitoyl-CoA + L-serine = CoA + 3-dehydro-D-sphinganine + CO(2).,cofactor:Pyridoxal phosphate.,pathway:Lipid metabolism; sphingolipid metabolism.,similarity:Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family.,subunit:SPTLC1, SPTLC2 and SPTLC3 may encode subunits of the enzyme.,tissue specificity:Widely expressed., |
| Subcellular location | Endoplasmic reticulum membrane ; Single-pass membrane protein . |
| Expression | Widely expressed. |
Additional Images
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Western blot analysis of lysates from SH-SY5Y cells, primary antibody was diluted at 1:1000, 4°over night
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: AO-06-ES12972-50
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