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Antibody Product Overview
| ELK.No | ES12978 |
| Product name | SPSY rabbit pAb |
| Reactivity | Human; Mouse |
| Applications | WB;ELISA;IHC |
| Other name | |
| Size | 100μL |
| Unit price ($) | 248 |
| Human gene ID | 6611 |
| Human Swiss-Prot | P52788 |
| Source | Rabbit |
| Isotype | IgG |
| Target | SPSY |
| Fields | >>Cysteine and methionine metabolism;>>Arginine and proline metabolism;>>Glutathione metabolism;>>Metabolic pathways |
| Gene name | SMS |
| Protein name | SPSY |
| Human gene link | View Human Gene |
| Human Swiss link | View Human Swiss-Prot |
| Mouse gene ID | 20603 |
| Mouse gene link | View Mouse Gene |
| Mouse Swiss-Prot | P97355 |
| Mouse Swiss link | View Mouse Swiss-Prot |
| Rat gene ID | |
| Rat gene link | |
| Rat Swiss-Prot | |
| Rat Swiss link | |
| Immunogen | Synthesized peptide derived from human SPSY AA range: 81-131 |
| Specificity | This antibody detects endogenous levels of SPSY at Human/Mouse |
| Formulation | Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide. |
| Clonality | Polyclonal |
| Dilution | WB 1:500-2000;IHC-p 1:50-300; ELISA 2000-20000 |
| Purification | The antibody was affinity-purified from rabbit serum by affinity-chromatography using specific immunogen. |
| Concentration | 1 mg/ml |
| Storage stability | -20°C/1 year |
| Molecular Weight (Da) | 40kD |
| Observed band (KD) | |
| Background | This gene encodes a protein belonging to the spermidine/spermin synthase family. Pseudogenes of this gene are located on chromosomes 1, 5, 6 and X. Mutations in this gene are associated with X-linked Snyder-Robinson mental retardation syndrome. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, May 2012], |
| Function | catalytic activity:S-adenosylmethioninamine + spermidine = 5'-methylthioadenosine + spermine.,disease:Defects in SMS are the cause of Snyder-Robinson syndrome (SRS) [MIM:309583]; also called X-linked mental retardation Snyder-Robinson type. SRS is characterized by moderate intellectual deficit, hypotonia, an unsteady gait, osteoporosis, kyphoscoliosis and facial asymmetry. Transmission is X-linked recessive.,domain:Composed of 3 domains: the N-terminal domain has structural similarity to S-adenosylmethionine decarboxylase, the central domain is made up of four beta strands and the C-terminal domain is similar in structure to spermidine synthase. The N- and C-terminal domains are both required for activity.,function:Required for normal viability, growth and fertility.,pathway:Amine and polyamine biosynthesis; spermine biosynthesis; spermine from spermidine: step 1/1.,similarity:Belongs to |
| Subcellular location | cytosol,extracellular exosome, |
| Expression |
Additional Images
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Western blot analysis of lysates from CACO2 cells, primary antibody was diluted at 1:1000, 4°over night
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Immunohistochemical analysis of paraffin-embedded human tonsil. 1, Antibody was diluted at 1:200(4° overnight). 2, Tris-EDTA,pH9.0 was used for antigen retrieval. 3,Secondary antibody was diluted at 1:200(room temperature, 45min).
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: AO-06-ES12978-100
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