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Antibody Product Overview
| ELK.No | ES12997 |
| Product name | SPC25 rabbit pAb |
| Reactivity | Human; Mouse;Rat |
| Applications | WB |
| Other name | |
| Size | 100μL |
| Unit price ($) | 248 |
| Human gene ID | 57405 |
| Human Swiss-Prot | Q9HBM1 |
| Source | Rabbit |
| Isotype | IgG |
| Target | SPC25 |
| Fields | |
| Gene name | SPC25 SPBC25 AD024 |
| Protein name | SPC25 |
| Human gene link | View Human Gene |
| Human Swiss link | View Human Swiss-Prot |
| Mouse gene ID | 66442 |
| Mouse gene link | View Mouse Gene |
| Mouse Swiss-Prot | Q3UA16 |
| Mouse Swiss link | View Mouse Swiss-Prot |
| Rat gene ID | 295661 |
| Rat gene link | View Rat Gene |
| Rat Swiss-Prot | Q5M856 |
| Rat Swiss link | View Rat Swiss-Prot |
| Immunogen | Synthesized peptide derived from human SPC25 AA range: 17-67 |
| Specificity | This antibody detects endogenous levels of SPC25 at Human/Mouse/Rat |
| Formulation | Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide. |
| Clonality | Polyclonal |
| Dilution | WB 1：500-2000 |
| Purification | The antibody was affinity-purified from rabbit serum by affinity-chromatography using specific immunogen. |
| Concentration | 1 mg/ml |
| Storage stability | -20°C/1 year |
| Molecular Weight (Da) | 25kD |
| Observed band (KD) | |
| Background | This gene encodes a protein that may be involved in kinetochore-microtubule interaction and spindle checkpoint activity. [provided by RefSeq, Jul 2008], |
| Function | function:Acts as a component of the essential kinetochore-associated NDC80 complex, which is required for chromosome segregation and spindle checkpoint activity. Required for kinetochore integrity and the organization of stable microtubule binding sites in the outer plate of the kinetochore.,similarity:Belongs to the SPC25 family.,subcellular location:Localizes to kinetochores from late prophase to anaphase. Localizes specifically to the outer plate of the kinetochore.,subunit:Component of the NDC80 complex, which consists of NDC80/HEC1, CDCA1, SPBC24 and SPBC25. The NDC80 complex is formed by two subcomplexes composed of NDC80/HEC1-CDCA1 and SPBC24-SPBC25. Each subcomplex is formed by parallel interactions through the coiled-coil domains of individual subunits. Formation of a tetrameric complex is mediated by interactions between the C-terminal regions of both subunits of the NDC80/HEC1 |
| Subcellular location | Nucleus. Chromosome, centromere, kinetochore . Localizes to kinetochores from late prophase to anaphase (PubMed:14738735). Localizes specifically to the outer plate of the kinetochore (PubMed:14738735, PubMed:14699129). . |
| Expression |
Additional Images
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Western blot analysis of lysates from KB cells, primary antibody was diluted at 1:1000, 4°over night
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: AO-06-ES12997-100
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