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Antibody Product Overview
| ELK.No | ES13102 |
| Product name | SIM1 rabbit pAb |
| Reactivity | Human; Mouse |
| Applications | WB |
| Other name | Single-minded homolog 1 (Class E basic helix-loop-helix protein 14) (bHLHe14) |
| Size | 100μL |
| Unit price ($) | 248 |
| Human gene ID | 6492 |
| Human Swiss-Prot | P81133 |
| Source | Rabbit |
| Isotype | IgG |
| Target | SIM1 |
| Fields | |
| Gene name | SIM1 BHLHE14 |
| Protein name | SIM1 |
| Human gene link | View Human Gene |
| Human Swiss link | View Human Swiss-Prot |
| Mouse gene ID | 20464 |
| Mouse gene link | View Mouse Gene |
| Mouse Swiss-Prot | Q61045 |
| Mouse Swiss link | View Mouse Swiss-Prot |
| Rat gene ID | |
| Rat gene link | |
| Rat Swiss-Prot | |
| Rat Swiss link | |
| Immunogen | Synthesized peptide derived from human SIM1 AA range: 545-595 |
| Specificity | This antibody detects endogenous levels of SIM1 at Human/Mouse |
| Formulation | Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.316% sodium azide. |
| Clonality | Polyclonal |
| Dilution | WB 1:500-2000 |
| Purification | The antibody was affinity-purified from rabbit serum by affinity-chromatography using specific immunogen. |
| Concentration | 1 mg/ml |
| Storage stability | -20°C/1 year |
| Molecular Weight (Da) | |
| Observed band (KD) | 85kD |
| Background | SIM1 and SIM2 genes are Drosophila single-minded (sim) gene homologs. SIM1 transcript was detected only in fetal kidney out of various adult and fetal tissues tested. Since the sim gene plays an important role in Drosophila development and has peak levels of expression during the period of neurogenesis,it was proposed that the human SIM gene is a candidate for involvement in certain dysmorphic features (particularly the facial and skull characteristics), abnormalities of brain development, and/or mental retardation of Down syndrome. [provided by RefSeq, Jul 2008], |
| Function | function:Transcriptional factor that may have pleiotropic effects during embryogenesis and in the adult.,similarity:Contains 1 basic helix-loop-helix (bHLH) domain.,similarity:Contains 1 PAC (PAS-associated C-terminal) domain.,similarity:Contains 1 Single-minded C-terminal domain.,similarity:Contains 2 PAS (PER-ARNT-SIM) domains.,subunit:Efficient DNA binding requires dimerization with another bHLH protein. Heterodimer of SIM1 and ARNT., |
| Subcellular location | Nucleus . |
| Expression |
Additional Images
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Western blot analysis of lysates from A549 cells, primary antibody was diluted at 1:1000, 4°over night
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: AO-06-ES13102-100
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