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Antibody Product Overview
| ELK.No | ES13114 |
| Product name | SHRM3 rabbit pAb |
| Reactivity | Human; Mouse |
| Applications | WB |
| Other name | |
| Size | 50μL |
| Unit price ($) | 148 |
| Human gene ID | 57619 |
| Human Swiss-Prot | Q8TF72 |
| Source | Rabbit |
| Isotype | IgG |
| Target | SHRM3 |
| Fields | |
| Gene name | SHROOM3 KIAA1481 SHRML MSTP013 |
| Protein name | SHRM3 |
| Human gene link | View Human Gene |
| Human Swiss link | View Human Swiss-Prot |
| Mouse gene ID | 27428 |
| Mouse gene link | View Mouse Gene |
| Mouse Swiss-Prot | Q9QXN0 |
| Mouse Swiss link | View Mouse Swiss-Prot |
| Rat gene ID | |
| Rat gene link | |
| Rat Swiss-Prot | |
| Rat Swiss link | |
| Immunogen | Synthesized peptide derived from human SHRM3 AA range: 777-827 |
| Specificity | This antibody detects endogenous levels of SHRM3 at Human/Mouse |
| Formulation | Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide. |
| Clonality | Polyclonal |
| Dilution | WB 1：500-2000 |
| Purification | The antibody was affinity-purified from rabbit serum by affinity-chromatography using specific immunogen. |
| Concentration | 1 mg/ml |
| Storage stability | -20°C/1 year |
| Molecular Weight (Da) | 220kD |
| Observed band (KD) | |
| Background | This gene encodes a PDZ-domain-containing protein that belongs to a family of Shroom-related proteins. This protein may be involved in regulating cell shape in certain tissues. A similar protein in mice is required for proper neurulation. [provided by RefSeq, Jan 2011], |
| Function | domain:The ASD1 domain mediates F-actin binding.,domain:The ASD2 domain is required for apical constriction induction.,function:Controls cell shape changes in the neuroepithelium during neural tube closure. Induces apical constriction in epithelial cells by promoting the apical accumulation of F-actin and myosin II, and probably by bundling stress fibers. Induces apicobasal cell elongation by redistributing gamma-tubulin and directing the assembly of robust apicobasal microtubule arrays.,similarity:Belongs to the shroom family.,similarity:Contains 1 ASD1 domain.,similarity:Contains 1 ASD2 domain.,similarity:Contains 1 PDZ (DHR) domain.,subcellular location:Colocalizes with F-actin in stress fibers and adherens junctions.,subunit:Interacts with F-actin., |
| Subcellular location | Cell junction, adherens junction . Cytoplasm, cytoskeleton . Apical cell membrane ; Peripheral membrane protein . Colocalizes with F-actin in stress fibers and adherens junctions. . |
| Expression |
Additional Images
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Western blot analysis of lysates from HuvEc cells, primary antibody was diluted at 1:1000, 4°over night
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: AO-06-ES13114-50
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