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Antibody Product Overview
| ELK.No | ES13214 |
| Product name | SAFB2 rabbit pAb |
| Reactivity | Human; Mouse |
| Applications | WB |
| Other name | Scaffold attachment factor B2 (SAF-B2) |
| Size | 50μL |
| Unit price ($) | 148 |
| Human gene ID | 9667 |
| Human Swiss-Prot | Q14151 |
| Source | Rabbit |
| Isotype | IgG |
| Target | SAFB2 |
| Fields | |
| Gene name | SAFB2 KIAA0138 |
| Protein name | SAFB2 |
| Human gene link | View Human Gene |
| Human Swiss link | View Human Swiss-Prot |
| Mouse gene ID | 224902 |
| Mouse gene link | View Mouse Gene |
| Mouse Swiss-Prot | Q80YR5 |
| Mouse Swiss link | View Mouse Swiss-Prot |
| Rat gene ID | |
| Rat gene link | |
| Rat Swiss-Prot | |
| Rat Swiss link | |
| Immunogen | Synthesized peptide derived from human SAFB2 AA range: 737-787 |
| Specificity | This antibody detects endogenous levels of SAFB2 at Human/Mouse |
| Formulation | Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.226% sodium azide. |
| Clonality | Polyclonal |
| Dilution | WB 1:500-2000 |
| Purification | The antibody was affinity-purified from rabbit serum by affinity-chromatography using specific immunogen. |
| Concentration | 1 mg/ml |
| Storage stability | -20°C/1 year |
| Molecular Weight (Da) | |
| Observed band (KD) | 105kD |
| Background | The protein encoded by this gene, along with its paralog (scaffold attachment factor B1), is a repressor of estrogen receptor alpha. The encoded protein binds scaffold/matrix attachment region (S/MAR) DNA and is involved in cell cycle regulation, apoptosis, differentiation, the stress response, and regulation of immune genes. [provided by RefSeq, May 2016], |
| Function | function:Binds to scaffold/matrix attachment region (S/MAR) DNA. Can function as an estrogen receptor corepressor and can also inhibit cell proliferation.,PTM:Phosphorylated upon DNA damage, probably by ATM or ATR.,similarity:Contains 1 RRM (RNA recognition motif) domain.,similarity:Contains 1 SAP domain.,subunit:Interacts with SAFB/SAFB1 and SCAM1.,tissue specificity:Expressed at high levels in the CNS and at low levels in the liver. Expressed in a wide number of breast cancer cell lines., |
| Subcellular location | Cytoplasm. Nucleus. |
| Expression | Expressed at high levels in the CNS and at low levels in the liver. Expressed in a wide number of breast cancer cell lines. |
Additional Images
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Western blot analysis of lysates from K562 cells, primary antibody was diluted at 1:1000, 4°over night
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: AO-06-ES13214-50
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