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Antibody Product Overview
| ELK.No | ES13394 |
| Product name | RIMB1 rabbit pAb |
| Reactivity | Human; Mouse;Rat |
| Applications | WB;IHC |
| Other name | |
| Size | 50μL |
| Unit price ($) | 148 |
| Human gene ID | 9256 |
| Human Swiss-Prot | O95153 |
| Source | Rabbit |
| Isotype | IgG |
| Target | RIMB1 |
| Fields | |
| Gene name | BZRAP1 KIAA0612 RBP1 RIMBP1 |
| Protein name | RIMB1 |
| Human gene link | View Human Gene |
| Human Swiss link | View Human Swiss-Prot |
| Mouse gene ID | 207777 |
| Mouse gene link | View Mouse Gene |
| Mouse Swiss-Prot | Q7TNF8 |
| Mouse Swiss link | View Mouse Swiss-Prot |
| Rat gene ID | |
| Rat gene link | |
| Rat Swiss-Prot | Q9JIR0 |
| Rat Swiss link | View Rat Swiss-Prot |
| Immunogen | Synthesized peptide derived from human RIMB1 AA range: 24-74 |
| Specificity | This antibody detects endogenous levels of RIMB1 at Human/Mouse/Rat |
| Formulation | Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide. |
| Clonality | Polyclonal |
| Dilution | WB 1:500-2000;IHC-p 1:50-300 |
| Purification | The antibody was affinity-purified from rabbit serum by affinity-chromatography using specific immunogen. |
| Concentration | 1 mg/ml |
| Storage stability | -20°C/1 year |
| Molecular Weight (Da) | 204kD |
| Observed band (KD) | |
| Background | |
| Function | caution:PubMed:9915832 demonstrated interaction with BZRP but later PubMed:12435798 demonstrated in the rat ortholog that is not associated with BZRP in the brain.,domain:The SH3 and proline-rich domain is required for the interaction with BZRP and the second SH3 domain mediates binding to a proline-rich motif in RIMS1 and RIMS2.,similarity:Belongs to the RIMBP family.,similarity:Contains 3 fibronectin type-III domains.,similarity:Contains 3 SH3 domains.,subcellular location:Preferentially expressed in the mitochondria in the presence of BZRP.,subunit:Interacts with RIMS1 and RIMS2 (By similarity). Interacts with BZRP.,tissue specificity:Predominantly expressed in brain, pituitary gland and thymus in adults. In adult brain, highest expression found in temporal lobe and the putamen, followed by amygdala, caudate nucleus, cerebral cortex, occipital and frontal lobe. A high expression level |
| Subcellular location | Cytoplasm . Mitochondrion . Preferentially expressed in the mitochondria in the presence of TSPO. |
| Expression | Predominantly expressed in brain, pituitary gland and thymus in adults. In adult brain, highest expression found in temporal lobe and the putamen, followed by amygdala, caudate nucleus, cerebral cortex, occipital and frontal lobe. A high expression level is also observed in fetal tissues like brain, heart, kidney and thymus. |
Additional Images
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Western blot analysis of lysates from Hela cells, primary antibody was diluted at 1:1000, 4°over night
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Immunohistochemical analysis of paraffin-embedded human tonsil. 1, Antibody was diluted at 1:200(4° overnight). 2, Tris-EDTA,pH9.0 was used for antigen retrieval. 3,Secondary antibody was diluted at 1:200(room temperature, 45min).
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: AO-06-ES13394-50
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