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Antibody Product Overview
| ELK.No | ES13973 |
| Product name | PRAF3 rabbit pAb |
| Reactivity | Human; Mouse;Rat |
| Applications | WB |
| Other name | |
| Size | 100μL |
| Unit price ($) | 248 |
| Human gene ID | 10550 |
| Human Swiss-Prot | O75915 |
| Source | Rabbit |
| Isotype | IgG |
| Target | PRAF3 |
| Fields | |
| Gene name | ARL6IP5 DERP11 JWA PRA2 PRAF3 HSPC127 |
| Protein name | PRAF3 |
| Human gene link | View Human Gene |
| Human Swiss link | View Human Swiss-Prot |
| Mouse gene ID | 65106 |
| Mouse gene link | View Mouse Gene |
| Mouse Swiss-Prot | Q8R5J9 |
| Mouse Swiss link | View Mouse Swiss-Prot |
| Rat gene ID | 66028 |
| Rat gene link | View Rat Gene |
| Rat Swiss-Prot | Q9ES40 |
| Rat Swiss link | View Rat Swiss-Prot |
| Immunogen | Synthesized peptide derived from human PRAF3 AA range: 120-170 |
| Specificity | This antibody detects endogenous levels of PRAF3 at Human/Mouse/Rat |
| Formulation | Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide. |
| Clonality | Polyclonal |
| Dilution | WB 1：500-2000 |
| Purification | The antibody was affinity-purified from rabbit serum by affinity-chromatography using specific immunogen. |
| Concentration | 1 mg/ml |
| Storage stability | -20°C/1 year |
| Molecular Weight (Da) | 21kD |
| Observed band (KD) | |
| Background | Expression of this gene is affected by vitamin A. The encoded protein of this gene may be associated with the cytoskeleton. A similar protein in rats may play a role in the regulation of cell differentiation. The rat protein binds and inhibits the cell membrane glutamate transporter EAAC1. The expression of the rat gene is upregulated by retinoic acid, which results in a specific reduction in EAAC1-mediated glutamate transport. [provided by RefSeq, Jul 2008], |
| Function | function:Regulates intracellular concentrations of taurine and glutamate. Negatively modulates SLC1A1/EAAC1 glutamate transport activity by decreasing its affinity for glutamate. May be involved in membrane traffic.,induction:By methyl-beta-cyclodextrin (By similarity). Up-regulated upon induced differentiation and in heat stress.,similarity:Belongs to the PRA1 family.,subcellular location:Also exists as a soluble form in the cytoplasm. Associated with microtubules.,subunit:Forms multimers. Binds to prenylated RAB1A and RAB3A, to the neuronal glutamate transporter SLC1A1/EAAC1, and to the ADP-ribosylation like factor ARL6, a member of the Ras superfamily. Does not bind to VAMP2., |
| Subcellular location | Endoplasmic reticulum membrane ; Multi-pass membrane protein . Cell membrane ; Multi-pass membrane protein . Cytoplasm . Cytoplasm, cytoskeleton . Also exists as a soluble form in the cytoplasm. Associated with microtubules. . |
| Expression |
Additional Images
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Western blot analysis of lysates from HpeG2 cells, primary antibody was diluted at 1:1000, 4°over night
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: AO-06-ES13973-100
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