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Antibody Product Overview
| ELK.No | ES14016 |
| Product name | PP12C rabbit pAb |
| Reactivity | Human; Mouse |
| Applications | WB;IHC |
| Other name | |
| Size | 50μL |
| Unit price ($) | 148 |
| Human gene ID | 54776 |
| Human Swiss-Prot | Q9BZL4 |
| Source | Rabbit |
| Isotype | IgG |
| Target | PP12C |
| Fields | >>Vascular smooth muscle contraction;>>Focal adhesion;>>Regulation of actin cytoskeleton;>>Oxytocin signaling pathway;>>Proteoglycans in cancer |
| Gene name | PPP1R12C LENG3 MBS85 |
| Protein name | PP12C |
| Human gene link | View Human Gene |
| Human Swiss link | View Human Swiss-Prot |
| Mouse gene ID | 232807 |
| Mouse gene link | View Mouse Gene |
| Mouse Swiss-Prot | Q3UMT1 |
| Mouse Swiss link | View Mouse Swiss-Prot |
| Rat gene ID | |
| Rat gene link | |
| Rat Swiss-Prot | |
| Rat Swiss link | |
| Immunogen | Synthesized peptide derived from human PP12C AA range: 542-592 |
| Specificity | This antibody detects endogenous levels of PP12C at Human/Mouse |
| Formulation | Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide. |
| Clonality | Polyclonal |
| Dilution | WB 1:500-2000;IHC-p 1:50-300 |
| Purification | The antibody was affinity-purified from rabbit serum by affinity-chromatography using specific immunogen. |
| Concentration | 1 mg/ml |
| Storage stability | -20°C/1 year |
| Molecular Weight (Da) | 86kD |
| Observed band (KD) | |
| Background | The gene encodes a subunit of myosin phosphatase. The encoded protein regulates the catalytic activity of protein phosphatase 1 delta and assembly of the actin cytoskeleton. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Oct 2012], |
| Function | caution:Although assigned as two separate genes (PPP1R12C and LENG3), it is probable that LENG3 does not exist by itself and is a part of the PPP1R12C gene.,function:Regulates myosin phosphatase activity.,PTM:Phosphorylated upon DNA damage, probably by ATM or ATR.,sequence caution:Unspliced mRNA.,similarity:Contains 4 ANK repeats.,subcellular location:Along actomyosin filaments and stress fibers.,subunit:PP1 comprises a catalytic subunit, PPP1CA, PPP1CB or PPP1CC, and one or several targeting or regulatory subunits. PPP1R12C mediates binding to myosin. Interacts via its N-terminus with PPP1CB. Interacts with IL16. Interacts with the coiled-coil domain of MPRIP.,tissue specificity:Ubiquitously expressed. Highly expressed in heart., |
| Subcellular location | Cytoplasm . Cytoplasm, cytoskeleton, stress fiber . |
| Expression | Ubiquitously expressed. Highly expressed in heart. |
Additional Images
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Western blot analysis of lysates from VEC cells, primary antibody was diluted at 1:1000, 4°over night
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Immunohistochemical analysis of paraffin-embedded human liver cancer. 1, Antibody was diluted at 1:200(4° overnight). 2, Tris-EDTA,pH9.0 was used for antigen retrieval. 3,Secondary antibody was diluted at 1:200(room temperature, 45min).
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: AO-06-ES14016-50
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