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Antibody Product Overview
| ELK.No | ES14050 |
| Product name | PNCB rabbit pAb |
| Reactivity | Human; Mouse;Rat |
| Applications | WB;IHC |
| Other name | |
| Size | 100μL |
| Unit price ($) | 248 |
| Human gene ID | 93100 |
| Human Swiss-Prot | Q6XQN6 |
| Source | Rabbit |
| Isotype | IgG |
| Target | PNCB |
| Fields | >>Nicotinate and nicotinamide metabolism;>>Metabolic pathways;>>Biosynthesis of cofactors |
| Gene name | NAPRT1 FHIP |
| Protein name | PNCB |
| Human gene link | View Human Gene |
| Human Swiss link | View Human Swiss-Prot |
| Mouse gene ID | 223646 |
| Mouse gene link | View Mouse Gene |
| Mouse Swiss-Prot | Q8CC86 |
| Mouse Swiss link | View Mouse Swiss-Prot |
| Rat gene ID | 315085 |
| Rat gene link | View Rat Gene |
| Rat Swiss-Prot | Q6XQN1 |
| Rat Swiss link | View Rat Swiss-Prot |
| Immunogen | Synthesized peptide derived from human PNCB AA range: 134-184 |
| Specificity | This antibody detects endogenous levels of PNCB at Human/Mouse/Rat |
| Formulation | Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide. |
| Clonality | Polyclonal |
| Dilution | WB 1:500-2000;IHC-p 1:50-300 |
| Purification | The antibody was affinity-purified from rabbit serum by affinity-chromatography using specific immunogen. |
| Concentration | 1 mg/ml |
| Storage stability | -20°C/1 year |
| Molecular Weight (Da) | 59kD |
| Observed band (KD) | |
| Background | Nicotinic acid (NA; niacin) is converted by nicotinic acid phosphoribosyltransferase (NAPRT; EC 2.4.2.11) to NA mononucleotide (NaMN), which is then converted to NA adenine dinucleotide (NaAD), and finally to nicotinamide adenine dinucleotide (NAD), which serves as a coenzyme in cellular redox reactions and is an essential component of a variety of processes in cellular metabolism including response to stress (Hara et al., 2007).[supplied by OMIM, Mar 2008], |
| Function | catalytic activity:Nicotinate D-ribonucleotide + diphosphate = nicotinate + 5-phospho-alpha-D-ribose 1-diphosphate.,function:Catalyzes the conversion of nicotinic acid (NA) to NA mononucleotide (NaMN). Essential for NA to increase cellular NAD levels and prevent oxidative stress of the cells.,pathway:Cofactor biosynthesis; NAD(+) biosynthesis; nicotinate ribonucleotide from nicotinate: step 1/1.,similarity:Belongs to the NAPRTase family., |
| Subcellular location | Cytoplasm, cytosol . |
| Expression |
Additional Images
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Western blot analysis of lysates from Hela cells, primary antibody was diluted at 1:1000, 4°over night
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Immunohistochemical analysis of paraffin-embedded human tonsil. 1, Antibody was diluted at 1:200(4° overnight). 2, Tris-EDTA,pH9.0 was used for antigen retrieval. 3,Secondary antibody was diluted at 1:200(room temperature, 45min).
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: AO-06-ES14050-100
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