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Antibody Product Overview
| ELK.No | ES14053 |
| Product name | PMM1 rabbit pAb |
| Reactivity | Human; Mouse |
| Applications | WB;IHC |
| Other name | |
| Size | 50μL |
| Unit price ($) | 148 |
| Human gene ID | 5372 |
| Human Swiss-Prot | Q92871 |
| Source | Rabbit |
| Isotype | IgG |
| Target | PMM1 |
| Fields | >>Fructose and mannose metabolism;>>Amino sugar and nucleotide sugar metabolism;>>Metabolic pathways;>>Biosynthesis of cofactors;>>Biosynthesis of nucleotide sugars |
| Gene name | PMM1 PMMH22 |
| Protein name | PMM1 |
| Human gene link | View Human Gene |
| Human Swiss link | View Human Swiss-Prot |
| Mouse gene ID | 29858 |
| Mouse gene link | View Mouse Gene |
| Mouse Swiss-Prot | O35621 |
| Mouse Swiss link | View Mouse Swiss-Prot |
| Rat gene ID | |
| Rat gene link | |
| Rat Swiss-Prot | |
| Rat Swiss link | |
| Immunogen | Synthesized peptide derived from human PMM1 AA range: 18-68 |
| Specificity | This antibody detects endogenous levels of PMM1 at Human/Mouse |
| Formulation | Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide. |
| Clonality | Polyclonal |
| Dilution | WB 1:500-2000;IHC-p 1:50-300 |
| Purification | The antibody was affinity-purified from rabbit serum by affinity-chromatography using specific immunogen. |
| Concentration | 1 mg/ml |
| Storage stability | -20°C/1 year |
| Molecular Weight (Da) | 29kD |
| Observed band (KD) | |
| Background | Phosphomannomutase catalyzes the conversion between D-mannose 6-phosphate and D-mannose 1-phosphate which is a substrate for GDP-mannose synthesis. GDP-mannose is used for synthesis of dolichol-phosphate-mannose, which is essential for N-linked glycosylation and thus the secretion of several glycoproteins as well as for the synthesis of glycosyl-phosphatidyl-inositol (GPI) anchored proteins. [provided by RefSeq, Jul 2008], |
| Function | catalytic activity:Alpha-D-mannose 1-phosphate = D-mannose 6-phosphate.,function:Involved in the synthesis of the GDP-mannose and dolichol-phosphate-mannose required for a number of critical mannosyl transfer reactions.,pathway:Nucleotide-sugar biosynthesis; GDP-D-mannose biosynthesis; alpha-D-mannose 1-phosphate from D-fructose 6-phosphate: step 2/2.,similarity:Belongs to the eukaryotic PMM family.,tissue specificity:Strong expression in liver, heart, brain, and pancreas; lower expression in skeletal muscle., |
| Subcellular location | Cytoplasm . |
| Expression | Strong expression in liver, heart, brain, and pancreas; lower expression in skeletal muscle. |
Additional Images
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Western blot analysis of lysates from Hela cells, primary antibody was diluted at 1:1000, 4°over night
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Immunohistochemical analysis of paraffin-embedded human liver cancer. 1, Antibody was diluted at 1:200(4° overnight). 2, Tris-EDTA,pH9.0 was used for antigen retrieval. 3,Secondary antibody was diluted at 1:200(room temperature, 45min).
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: AO-06-ES14053-50
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