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Antibody Product Overview
| ELK.No | ES14109 |
| Product name | PIGZ rabbit pAb |
| Reactivity | Human; Mouse |
| Applications | WB;ELISA;IHC |
| Other name | |
| Size | 50μL |
| Unit price ($) | 148 |
| Human gene ID | 80235 |
| Human Swiss-Prot | Q86VD9 |
| Source | Rabbit |
| Isotype | IgG |
| Target | PIGZ |
| Fields | >>Glycosylphosphatidylinositol (GPI)-anchor biosynthesis |
| Gene name | PIGZ SMP3 |
| Protein name | PIGZ |
| Human gene link | View Human Gene |
| Human Swiss link | View Human Swiss-Prot |
| Mouse gene ID | 239827 |
| Mouse gene link | View Mouse Gene |
| Mouse Swiss-Prot | Q8BTP0 |
| Mouse Swiss link | View Mouse Swiss-Prot |
| Rat gene ID | |
| Rat gene link | |
| Rat Swiss-Prot | |
| Rat Swiss link | |
| Immunogen | Synthesized peptide derived from human PIGZ AA range: 251-301 |
| Specificity | This antibody detects endogenous levels of PIGZ at Human/Mouse |
| Formulation | Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide. |
| Clonality | Polyclonal |
| Dilution | WB 1:500-2000;IHC-p 1:50-300; ELISA 2000-20000 |
| Purification | The antibody was affinity-purified from rabbit serum by affinity-chromatography using specific immunogen. |
| Concentration | 1 mg/ml |
| Storage stability | -20°C/1 year |
| Molecular Weight (Da) | 64kD |
| Observed band (KD) | |
| Background | The glycosylphosphatidylinositol (GPI) anchor is a glycolipid found on many blood cells that serves to anchor proteins to the cell surface. This gene encodes a protein that is localized to the endoplasmic reticulum, and is involved in GPI anchor biosynthesis. As shown for the yeast homolog, which is a member of a family of dolichol-phosphate-mannose (Dol-P-Man)-dependent mannosyltransferases, this protein can also add a side-branching fourth mannose to GPI precursors during the assembly of GPI anchors. [provided by RefSeq, Jul 2008], |
| Function | caution:It is uncertain whether Met-1 or Met-32 is the initiator.,function:Mannosyltransferase involved in glycosylphosphatidylinositol-anchor biosynthesis. Transfers a fourth mannose to some trimannosyl-GPIs during GPI precursor assembly. The presence of a fourth mannose in GPI is facultative and only scarcely detected, suggesting that it only exists in some tissues.,pathway:Glycolipid biosynthesis; glycosylphosphatidylinositol-anchor biosynthesis.,similarity:Belongs to the glycosyltransferase 22 family. PIGZ subfamily.,tissue specificity:Widely expressed at low level, with highest level in brain and colon., |
| Subcellular location | Endoplasmic reticulum membrane ; Multi-pass membrane protein . |
| Expression | Widely expressed at low level, with highest level in brain and colon. |
Additional Images
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Western blot analysis of lysates from THP-1 cells, primary antibody was diluted at 1:1000, 4°over night
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Immunohistochemical analysis of paraffin-embedded human Breast cancer. 1, Antibody was diluted at 1:200(4° overnight). 2, Tris-EDTA,pH9.0 was used for antigen retrieval. 3,Secondary antibody was diluted at 1:200(room temperature, 45min).
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: AO-06-ES14109-50
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