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Antibody Product Overview
| ELK.No | ES14115 |
| Product name | PI51A rabbit pAb |
| Reactivity | Human; Mouse |
| Applications | WB |
| Other name | Phosphatidylinositol 4-phosphate 5-kinase type-1 alpha (PIP5K1-alpha) (PtdIns(4)P-5-kinase 1 alpha) (EC 2.7.1.68) (68 kDa type I phosphatidylinositol 4-phosphate 5-kinase alpha) (Phosphatidylinositol 4-phosphate 5-kinase type I alpha) (PIP5KIalpha) |
| Size | 100μL |
| Unit price ($) | 248 |
| Human gene ID | 8394 |
| Human Swiss-Prot | Q99755 |
| Source | Rabbit |
| Isotype | IgG |
| Target | PI51A |
| Fields | >>Inositol phosphate metabolism;>>Metabolic pathways;>>Phosphatidylinositol signaling system;>>Phospholipase D signaling pathway;>>Endocytosis;>>Focal adhesion;>>Fc gamma R-mediated phagocytosis;>>Regulation of actin cytoskeleton;>>Yersinia infection;>>Choline metabolism in cancer |
| Gene name | PIP5K1A |
| Protein name | PI51A |
| Human gene link | View Human Gene |
| Human Swiss link | View Human Swiss-Prot |
| Mouse gene ID | 18720 |
| Mouse gene link | View Mouse Gene |
| Mouse Swiss-Prot | P70182 |
| Mouse Swiss link | View Mouse Swiss-Prot |
| Rat gene ID | |
| Rat gene link | |
| Rat Swiss-Prot | |
| Rat Swiss link | |
| Immunogen | Synthesized peptide derived from human PI51A AA range: 270-320 |
| Specificity | This antibody detects endogenous levels of PI51A at Human/Mouse |
| Formulation | Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.99% sodium azide. |
| Clonality | Polyclonal |
| Dilution | WB 1:500-2000 |
| Purification | The antibody was affinity-purified from rabbit serum by affinity-chromatography using specific immunogen. |
| Concentration | 1 mg/ml |
| Storage stability | -20°C/1 year |
| Molecular Weight (Da) | |
| Observed band (KD) | 60kD |
| Background | |
| Function | catalytic activity:ATP + 1-phosphatidyl-1D-myo-inositol 4-phosphate = ADP + 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate.,function:Participates in the biosynthesis of phosphatidylinositol-4,5-bisphosphate. Mediates RAC1-dependent reorganization of actin filaments. Contributes to the activation of PLD2.,similarity:Contains 1 PI5K domain.,subcellular location:Associated with the plasma membrane and with internal membranes. Associated with Golgi stacks (By similarity). Detected on RAC1-induced plasma membrane ruffles, and on membrane ruffles induced by platelet-derived growth factor.,subunit:Interacts with ARF1, RAC1, PLD1, PLD2 and JUB.,tissue specificity:Highly expressed in heart, placenta, skeletal muscle, kidney and pancreas. Detected at lower levels in brain, lung and liver., |
| Subcellular location | Cell membrane . Cytoplasm . Nucleus . Nucleus speckle . Cell projection, ruffle . Cell projection, lamellipodium . Colocalizes with RAC1 at actin-rich membrane ruffles (PubMed:20660631). Localizes to nuclear speckles and associates with TUT1 to regulate polyadenylation of selected mRNAs (PubMed:18288197). . |
| Expression | Highly expressed in heart, placenta, skeletal muscle, kidney and pancreas. Detected at lower levels in brain, lung and liver. |
Additional Images
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Western blot analysis of lysates from AD293 cells, primary antibody was diluted at 1:1000, 4°over night
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: AO-06-ES14115-100
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