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PI3 Kinase Class III (phospho-Ser249) rabbit pAb
AO-06-ES14121-100
Antibody Product Overview
| ELK.No | ES14121 |
| Product name | PI3 Kinase Class III (phospho-Ser249) rabbit pAb |
| Reactivity | Human;Rat;Mouse; |
| Applications | WB;ELISA;IHC |
| Other name | Phosphatidylinositol 3-kinase catalytic subunit type 3 (PI3-kinase type 3) (PI3K type 3) (PtdIns-3-kinase type 3) (EC 2.7.1.137) (Phosphatidylinositol 3-kinase p100 subunit) (Phosphoinositide-3-kinase class 3) (hVps34) |
| Size | 100μL |
| Unit price ($) | 248 |
| Human gene ID | 5289 |
| Human Swiss-Prot | Q8NEB9 |
| Source | Rabbit |
| Isotype | IgG |
| Target | PI 3 Kinase Class 3 |
| Fields | >>Inositol phosphate metabolism;>>Metabolic pathways;>>Phosphatidylinositol signaling system;>>Autophagy - other;>>Autophagy - animal;>>Phagosome;>>Apelin signaling pathway;>>Alzheimer disease;>>Amyotrophic lateral sclerosis;>>Huntington disease;>>Spinocerebellar ataxia;>>Pathways of neurodegeneration - multiple diseases;>>Shigellosis;>>Salmonella infection;>>Tuberculosis;>>Kaposi sarcoma-associated herpesvirus infection |
| Gene name | PIK3C3 VPS34 |
| Protein name | PI3 Kinase Class III (Ser249) |
| Human gene link | View Human Gene |
| Human Swiss link | View Human Swiss-Prot |
| Mouse gene ID | 225326 |
| Mouse gene link | View Mouse Gene |
| Mouse Swiss-Prot | Q6PF93 |
| Mouse Swiss link | View Mouse Swiss-Prot |
| Rat gene ID | 65052 |
| Rat gene link | View Rat Gene |
| Rat Swiss-Prot | O88763 |
| Rat Swiss link | View Rat Swiss-Prot |
| Immunogen | Synthesized phosho peptide around human PI3 Kinase Class III (Ser249) |
| Specificity | This antibody detects endogenous levels of Human PI3 Kinase Class III (phospho-Ser249) |
| Formulation | Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide. |
| Clonality | Polyclonal |
| Dilution | WB 1:500-2000;IHC-p 1:50-300; ELISA 2000-20000 |
| Purification | The antibody was affinity-purified from rabbit serum by affinity-chromatography using specific immunogen. |
| Concentration | 1 mg/ml |
| Storage stability | -20°C/1 year |
| Molecular Weight (Da) | |
| Observed band (KD) | 100kD |
| Background | |
| Function | catalytic activity:ATP + 1-phosphatidyl-1D-myo-inositol = ADP + 1-phosphatidyl-1D-myo-inositol 3-phosphate.,cofactor:Manganese.,function:Catalytic subunit of the PI3K complex. Involved in the transport of lysosomal enzyme precursors to lysosomes.,similarity:Belongs to the PI3/PI4-kinase family.,similarity:Contains 1 PI3K/PI4K domain.,subunit:Probably forms a complex with AMBRA1 and BECN1 (By similarity). Heterodimer. This subunit, part of a complex composed of regulatory and catalytic subunits, associates with regulatory subunit PIK3R4.,tissue specificity:Ubiquitously expressed, with a highest expression in skeletal muscle., |
| Subcellular location | Midbody . Late endosome . Cytoplasmic vesicle, autophagosome . As component of the PI3K complex I localized to pre-autophagosome structures. As component of the PI3K complex II localized predominantly to endosomes (PubMed:14617358). Localizes also to discrete punctae along the ciliary axoneme and to the base of the ciliary axoneme (By similarity). . |
| Expression | Ubiquitously expressed, with a highest expression in skeletal muscle. |
Additional Images
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Immunohistochemical analysis of paraffin-embedded human Colon cancer. 1, Antibody was diluted at 1:200(4° overnight). 2, Tris-EDTA,pH9.0 was used for antigen retrieval. 3,Secondary antibody was diluted at 1:200(room temperature, 45min).
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Western Blot analysis of 1 Jurkat treated with LPS, 2 Jurkat ,using primary antibody at 1:1000 dilution. Secondary antibody(catalog#:RS23920) was diluted at 1:10000
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