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Antibody Product Overview
| ELK.No | ES14243 |
| Product name | PBIP1 rabbit pAb |
| Reactivity | Human; Mouse;Rat |
| Applications | WB |
| Other name | |
| Size | 50μL |
| Unit price ($) | 148 |
| Human gene ID | 57326 |
| Human Swiss-Prot | Q96AQ6 |
| Source | Rabbit |
| Isotype | IgG |
| Target | PBIP1 |
| Fields | |
| Gene name | PBXIP1 HPIP |
| Protein name | PBIP1 |
| Human gene link | View Human Gene |
| Human Swiss link | View Human Swiss-Prot |
| Mouse gene ID | 229534 |
| Mouse gene link | View Mouse Gene |
| Mouse Swiss-Prot | Q3TVI8 |
| Mouse Swiss link | View Mouse Swiss-Prot |
| Rat gene ID | 310644 |
| Rat gene link | View Rat Gene |
| Rat Swiss-Prot | A2VD12 |
| Rat Swiss link | View Rat Swiss-Prot |
| Immunogen | Synthesized peptide derived from human PBIP1 AA range: 585-635 |
| Specificity | This antibody detects endogenous levels of PBIP1 at Human/Mouse/Rat |
| Formulation | Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide. |
| Clonality | Polyclonal |
| Dilution | WB 1：500-2000 |
| Purification | The antibody was affinity-purified from rabbit serum by affinity-chromatography using specific immunogen. |
| Concentration | 1 mg/ml |
| Storage stability | -20°C/1 year |
| Molecular Weight (Da) | 80kD |
| Observed band (KD) | |
| Background | The protein encoded by this gene interacts with the PBX1 homeodomain protein, inhibiting its transcriptional activation potential by preventing its binding to DNA. The encoded protein, which is primarily cytosolic but can shuttle to the nucleus, also can interact with estrogen receptors alpha and beta and promote the proliferation of breast cancer, brain tumors, and lung cancer. Several transcript variants encoding different isoforms have been found for this gene. More variants exist, but their full-length natures have yet to be determined. [provided by RefSeq, Dec 2015], |
| Function | domain:Association to the cytoskeleton through a N-terminal leucine rich-domain (AA 190-218).,domain:The C-terminal domain (AA 443-731) contains a nuclear export signal.,function:Regulator of pre-B-cell leukemia transcription factors (BPXs) function. Inhibits the binding of PBX1-HOX complex to DNA and blocks the transcriptional activity of E2A-PBX1. Tethers estrogen receptor-alpha (ESR1) to microtubules and allows them to influence estrogen receptors-alpha signaling.,subcellular location:Shuttles between the nucleus and the cytosol. Mainly localized in the cytoplasm, associated with microtubules. Detected in small amounts in the nucleus.,subunit:Interacts with ESR1, PBX1, PBX2 and PBX3.,tissue specificity:Expressed in early hematopietic precursors., |
| Subcellular location | Cytoplasm, cytoskeleton . Nucleus . Shuttles between the nucleus and the cytosol (PubMed:12360403). Mainly localized in the cytoplasm, associated with microtubules (PubMed:10825160, PubMed:12360403). Detected in small amounts in the nucleus (PubMed:10825160). |
| Expression | Expressed in early hematopoietic precursors. |
Additional Images
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Western blot analysis of lysates from SW480 cells, primary antibody was diluted at 1:1000, 4°over night
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: AO-06-ES14243-50
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