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Antibody Product Overview
| ELK.No | ES14260 |
| Product name | PARG rabbit pAb |
| Reactivity | Human; Mouse;Rat |
| Applications | WB |
| Other name | |
| Size | 50μL |
| Unit price ($) | 148 |
| Human gene ID | 8505 |
| Human Swiss-Prot | Q86W56 |
| Source | Rabbit |
| Isotype | IgG |
| Target | PARG |
| Fields | |
| Gene name | PARG |
| Protein name | PARG |
| Human gene link | View Human Gene |
| Human Swiss link | View Human Swiss-Prot |
| Mouse gene ID | |
| Mouse gene link | |
| Mouse Swiss-Prot | O88622 |
| Mouse Swiss link | View Mouse Swiss-Prot |
| Rat gene ID | 83507 |
| Rat gene link | View Rat Gene |
| Rat Swiss-Prot | Q9QYM2 |
| Rat Swiss link | View Rat Swiss-Prot |
| Immunogen | Synthesized peptide derived from human PARG AA range: 140-190 |
| Specificity | This antibody detects endogenous levels of PARG at Human/Mouse/Rat |
| Formulation | Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide. |
| Clonality | Polyclonal |
| Dilution | WB 1：500-2000 |
| Purification | The antibody was affinity-purified from rabbit serum by affinity-chromatography using specific immunogen. |
| Concentration | 1 mg/ml |
| Storage stability | -20°C/1 year |
| Molecular Weight (Da) | 107kD |
| Observed band (KD) | |
| Background | This gene encodes a member of the serine protease family of hydrolytic enzymes which contain a serine in their active site. The encoded protein may play a role in activation of the antiviral prodrug valacyclovir. Alternatively spliced transcript variants have been described.[provided by RefSeq, Jan 2009], |
| Function | function:Serine hydrolase that catalyzes the hydrolytic activation of amino acid ester prodrugs of nucleoside analogs such as valacyclovir and valganciclovir. Activates valacyclovir to acyclovir. May play a role in detoxification processes.,similarity:Belongs to the AB hydrolase superfamily. Lipase family.,subunit:Monomer.,tissue specificity:Expressed at high levels in liver and kidney and lower levels in heart, intestine and skeletal muscle., |
| Subcellular location | [Isoform 1]: Nucleus . Colocalizes with PCNA at replication foci (PubMed:21398629). Relocalizes to the cytoplasm in response to DNA damage (PubMed:16460818). .; [Isoform 2]: Cytoplasm . Translocates to the nucleus in response to DNA damage. .; [Isoform 3]: Cytoplasm .; [Isoform 4]: Cytoplasm . Mitochondrion .; [Isoform 5]: Mitochondrion matrix . |
| Expression | Ubiquitously expressed. |
Additional Images
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Western blot analysis of lysates from CACO2 cells, primary antibody was diluted at 1:1000, 4°over night
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: AO-06-ES14260-50
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