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Antibody Product Overview
| ELK.No | ES14364 |
| Product name | OSBP1 rabbit pAb |
| Reactivity | Human; Mouse |
| Applications | WB |
| Other name | |
| Size | 100μL |
| Unit price ($) | 248 |
| Human gene ID | 5007 |
| Human Swiss-Prot | P22059 |
| Source | Rabbit |
| Isotype | IgG |
| Target | OSBP1 |
| Fields | |
| Gene name | OSBP OSBP1 |
| Protein name | OSBP1 |
| Human gene link | View Human Gene |
| Human Swiss link | View Human Swiss-Prot |
| Mouse gene ID | 76303 |
| Mouse gene link | View Mouse Gene |
| Mouse Swiss-Prot | Q3B7Z2 |
| Mouse Swiss link | View Mouse Swiss-Prot |
| Rat gene ID | |
| Rat gene link | |
| Rat Swiss-Prot | |
| Rat Swiss link | |
| Immunogen | Synthesized peptide derived from human OSBP1 AA range: 284-334 |
| Specificity | This antibody detects endogenous levels of OSBP1 at Human/Mouse |
| Formulation | Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide. |
| Clonality | Polyclonal |
| Dilution | WB 1：500-2000 |
| Purification | The antibody was affinity-purified from rabbit serum by affinity-chromatography using specific immunogen. |
| Concentration | 1 mg/ml |
| Storage stability | -20°C/1 year |
| Molecular Weight (Da) | 89kD |
| Observed band (KD) | |
| Background | Oxysterol binding protein is an intracellular protein that is believed to transport sterols from lysosomes to the nucleus where the sterol down-regulates the genes for the LDL receptor, HMG-CoA reductase, and HMG synthetase [provided by RefSeq, Jul 2008], |
| Function | domain:The PH and Ala/Gly-rich domains control cholesterol binding without affecting 25-hydroxycholesterol binding.,domain:The second coiled-coil domain is required for interaction with the tyrosine phosphatase.,function:Binds cholesterol and a range of oxysterols. Cholesterol binding promotes the formation of a complex with PP2A and a tyrosine phosphatase which dephosphorylate ERK1/2, whereas 25-hydroxycholesterol causes its disassembly. Regulates cholesterol efflux by decreasing ABCA1 stability.,similarity:Belongs to the OSBP family.,similarity:Contains 1 PH domain.,subcellular location:When bound to oxysterols, translocates to the periphery of Golgi membranes.,subunit:Homodimer or homotrimer.,tissue specificity:Widely expressed., |
| Subcellular location | Cytoplasm, cytosol . Cytoplasm, perinuclear region . Golgi apparatus membrane; Peripheral membrane protein . Endoplasmic reticulum membrane; Peripheral membrane protein . Golgi apparatus, trans-Golgi network . Predominantly cytosolic. . |
| Expression | Widely expressed. |
Additional Images
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Western blot analysis of lysates from U2OS cells, primary antibody was diluted at 1:1000, 4°over night
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: AO-06-ES14364-100
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