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Antibody Product Overview
| ELK.No | ES13321 |
| Product name | RT4I1 rabbit pAb |
| Reactivity | Human; Mouse |
| Applications | WB |
| Other name | |
| Size | 100μL |
| Unit price ($) | 248 |
| Human gene ID | 84816 |
| Human Swiss-Prot | Q8WWV3 |
| Source | Rabbit |
| Isotype | IgG |
| Target | RT4I1 |
| Fields | |
| Gene name | RTN4IP1 NIMP |
| Protein name | RT4I1 |
| Human gene link | View Human Gene |
| Human Swiss link | View Human Swiss-Prot |
| Mouse gene ID | 170728 |
| Mouse gene link | View Mouse Gene |
| Mouse Swiss-Prot | Q924D0 |
| Mouse Swiss link | View Mouse Swiss-Prot |
| Rat gene ID | |
| Rat gene link | |
| Rat Swiss-Prot | |
| Rat Swiss link | |
| Immunogen | Synthesized peptide derived from human RT4I1 AA range: 282-332 |
| Specificity | This antibody detects endogenous levels of RT4I1 at Human/Mouse |
| Formulation | Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide. |
| Clonality | Polyclonal |
| Dilution | WB 1：500-2000 |
| Purification | The antibody was affinity-purified from rabbit serum by affinity-chromatography using specific immunogen. |
| Concentration | 1 mg/ml |
| Storage stability | -20°C/1 year |
| Molecular Weight (Da) | 44kD |
| Observed band (KD) | |
| Background | This gene encodes a mitochondrial protein that interacts with reticulon 4, which is a potent inhibitor of regeneration following spinal cord injury. This interaction may be important for reticulon-induced inhibition of neurite growth. Mutations in this gene can cause optic atrophy 10, with or without ataxia, mental retardation, and seizures. There is a pseudogene for this gene on chromosome 12. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jan 2016], |
| Function | function:Appears to be a potent inhibitor of regeneration following spinal cord injury.,similarity:Belongs to the zinc-containing alcohol dehydrogenase family. Quinone oxidoreductase subfamily.,subunit:Interacts with RTN4, UQCRC1 and UQCRC2.,tissue specificity:Widely expressed in mitochondria-enriched tissues. Found in heart, muscle, kidney, liver, brain and placenta., |
| Subcellular location | Mitochondrion outer membrane . Colocalizes with the endoplasmic reticulum HSPA5 at spots corresponding to contacts with mitochondria. . |
| Expression | Widely expressed in mitochondria-enriched tissues. Found in heart, muscle, kidney, liver, brain and placenta. |
Additional Images
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Western blot analysis of lysates from HpeG2 cells, primary antibody was diluted at 1:1000, 4°over night
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: AO-06-ES13321-100
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