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ICAM-1 (phospho Tyr512) rabbit pAb
AO-06-ES1333-100
Antibody Product Overview
| ELK.No | ES1333 |
| Product name | ICAM-1 (phospho Tyr512) rabbit pAb |
| Reactivity | Human;Rat;Mouse; |
| Applications | WB;ELISA |
| Other name | ICAM1; Intercellular adhesion molecule 1; ICAM-1; Major group rhinovirus receptor; CD antigen CD54 |
| Size | 100μL |
| Unit price ($) | 248 |
| Human gene ID | 3383 |
| Human Swiss-Prot | P05362 |
| Source | Rabbit |
| Isotype | IgG |
| Target | ICAM-1 |
| Fields | >>NF-kappa B signaling pathway;>>Cell adhesion molecules;>>Natural killer cell mediated cytotoxicity;>>TNF signaling pathway;>>Leukocyte transendothelial migration;>>AGE-RAGE signaling pathway in diabetic complications;>>African trypanosomiasis;>>Malaria;>>Staphylococcus aureus infection;>>Influenza A;>>Human T-cell leukemia virus 1 infection;>>Kaposi sarcoma-associated herpesvirus infection;>>Epstein-Barr virus infection;>>Rheumatoid arthritis;>>Viral myocarditis;>>Lipid and atherosclerosis;>>Fluid shear stress and atherosclerosis |
| Gene name | ICAM1 |
| Protein name | Intercellular adhesion molecule 1 |
| Human gene link | View Human Gene |
| Human Swiss link | View Human Swiss-Prot |
| Mouse gene ID | |
| Mouse gene link | |
| Mouse Swiss-Prot | P13597 |
| Mouse Swiss link | View Mouse Swiss-Prot |
| Rat gene ID | |
| Rat gene link | |
| Rat Swiss-Prot | |
| Rat Swiss link | |
| Immunogen | The antiserum was produced against synthesized peptide derived from human ICAM-1 around the phosphorylation site of Tyr512. AA range:479-528 |
| Specificity | Phospho-ICAM-1 (Y512) Polyclonal Antibody detects endogenous levels of ICAM-1 protein only when phosphorylated at Y512. |
| Formulation | Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide. |
| Clonality | Polyclonal |
| Dilution | Western Blot: 1/500 - 1/2000. ELISA: 1/40000. Not yet tested in other applications. |
| Purification | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Concentration | 1 mg/ml |
| Storage stability | -20°C/1 year |
| Molecular Weight (Da) | |
| Observed band (KD) | 57kD |
| Background | This gene encodes a cell surface glycoprotein which is typically expressed on endothelial cells and cells of the immune system. It binds to integrins of type CD11a / CD18, or CD11b / CD18 and is also exploited by Rhinovirus as a receptor. [provided by RefSeq, Jul 2008], |
| Function | function:ICAM proteins are ligands for the leukocyte adhesion protein LFA-1 (integrin alpha-L/beta-2). During leukocyte trans-endothelial migration, ICAM1 engagement promotes the assembly of endothelial apical cups through SGEF and RHOG activation. In case of rhinovirus infection acts as a cellular receptor for the virus.,online information:ICAM-1,online information:Icosahedral capsid structure,online information:Intercellular adhesion molecule entry,polymorphism:Homozygotes with ICAM1-Kalifi Met-56 seem to have an increased risk for cerebral malaria.,PTM:Monoubiquitinated, which is promoted by MARCH9 and leads to endocytosis.,similarity:Belongs to the immunoglobulin superfamily. ICAM family.,similarity:Contains 5 Ig-like C2-type (immunoglobulin-like) domains.,subunit:Homodimer (Probable). Interacts with human herpesvirus 8 MIR2 protein (Probable). Interacts with MUC1 and promotes cell a |
| Subcellular location | Membrane; Single-pass type I membrane protein. |
| Expression | Blood,Kidney,Liver,Melanoma,Plasma, |
Additional Images
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Western Blot analysis of various cells using Phospho-ICAM-1 (Y512) Polyclonal Antibody diluted at 1:500
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Western blot analysis of lysates from HeLa cells treated with TNF-alpha 20ng/ml 5', using ICAM-1 (Phospho-Tyr512) Antibody. The lane on the right is blocked with the phospho peptide.
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: AO-06-ES1333-100
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