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Antibody Product Overview
| ELK.No | ES13331 |
| Product name | RRP44 rabbit pAb |
| Reactivity | Human; Mouse |
| Applications | WB |
| Other name | Exosome complex exonuclease RRP44 (EC 3.1.13.-) (EC 3.1.26.-) (Protein DIS3 homolog) (Ribosomal RNA-processing protein 44) |
| Size | 50μL |
| Unit price ($) | 148 |
| Human gene ID | 22894 |
| Human Swiss-Prot | Q9Y2L1 |
| Source | Rabbit |
| Isotype | IgG |
| Target | RRP44 |
| Fields | >>RNA degradation |
| Gene name | DIS3 KIAA1008 RRP44 |
| Protein name | RRP44 |
| Human gene link | View Human Gene |
| Human Swiss link | View Human Swiss-Prot |
| Mouse gene ID | 72662 |
| Mouse gene link | View Mouse Gene |
| Mouse Swiss-Prot | Q9CSH3 |
| Mouse Swiss link | View Mouse Swiss-Prot |
| Rat gene ID | |
| Rat gene link | |
| Rat Swiss-Prot | |
| Rat Swiss link | |
| Immunogen | Synthesized peptide derived from human RRP44 AA range: 262-312 |
| Specificity | This antibody detects endogenous levels of RRP44 at Human/Mouse |
| Formulation | Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.250% sodium azide. |
| Clonality | Polyclonal |
| Dilution | WB 1:500-2000 |
| Purification | The antibody was affinity-purified from rabbit serum by affinity-chromatography using specific immunogen. |
| Concentration | 1 mg/ml |
| Storage stability | -20°C/1 year |
| Molecular Weight (Da) | |
| Observed band (KD) | 105kD |
| Background | |
| Function | function:Component of the exosome 3'->5' exoribonuclease complex. Required for the 3'-processing of the 7S pre-RNA to the mature nuclear complex. Also associated with the GTPase Ran. Has a 3'-5' exonuclease activity.,similarity:Belongs to the ribonuclease II (RNB) family.,similarity:Contains 1 PINc domain.,subunit:Component of the exosome multienzyme ribonuclease complex composed of at least 11 proteins: RRP4, RRP40, RRP41/SKI6, RRP42, RRP43, RRP44/DIS3, PM/Scl-75, RRP46, CSL4 and PM/Scl-100 (only in the nuclear complex). Also associated with the GTPase Ran.,tissue specificity:Widely expressed., |
| Subcellular location | Cytoplasm . Nucleus, nucleolus . Nucleus, nucleoplasm . Nucleus . Predominantly located in the nucleus (PubMed:20531386). According to PubMed:12429849, found in the nucleolus (PubMed:12429849). According to PubMed:20531386, excluded from nucleolus supporting the existence of a nucleolar RNA exosome complex devoid of DIS3 (PubMed:20531386). . |
| Expression | Widely expressed. |
Additional Images
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Western blot analysis of lysates from 293T cells, primary antibody was diluted at 1:1000, 4°over night
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: AO-06-ES13331-50
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