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Antibody Product Overview
| ELK.No | ES13335 |
| Product name | RPH3L rabbit pAb |
| Reactivity | Human; Mouse;Rat |
| Applications | WB |
| Other name | |
| Size | 50μL |
| Unit price ($) | 148 |
| Human gene ID | 9501 |
| Human Swiss-Prot | Q9UNE2 |
| Source | Rabbit |
| Isotype | IgG |
| Target | RPH3L |
| Fields | |
| Gene name | RPH3AL NOC2 |
| Protein name | RPH3L |
| Human gene link | View Human Gene |
| Human Swiss link | View Human Swiss-Prot |
| Mouse gene ID | 380714 |
| Mouse gene link | View Mouse Gene |
| Mouse Swiss-Prot | Q768S4 |
| Mouse Swiss link | View Mouse Swiss-Prot |
| Rat gene ID | 171123 |
| Rat gene link | View Rat Gene |
| Rat Swiss-Prot | O54880 |
| Rat Swiss link | View Rat Swiss-Prot |
| Immunogen | Synthesized peptide derived from human RPH3L AA range: 162-212 |
| Specificity | This antibody detects endogenous levels of RPH3L at Human/Mouse/Rat |
| Formulation | Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide. |
| Clonality | Polyclonal |
| Dilution | WB 1：500-2000 |
| Purification | The antibody was affinity-purified from rabbit serum by affinity-chromatography using specific immunogen. |
| Concentration | 1 mg/ml |
| Storage stability | -20°C/1 year |
| Molecular Weight (Da) | 35kD |
| Observed band (KD) | |
| Background | The protein encoded by this gene plays a direct regulatory role in calcium-ion-dependent exocytosis in both endocrine and exocrine cells and plays a key role in insulin secretion by pancreatic cells. This gene is likely a tumor suppressor. Alternative splicing results in multiple transcript variants encoding distinct isoforms. [provided by RefSeq, Jun 2010], |
| Function | domain:The N-terminus of the RabBD domain is necessary and sufficient for interaction with RAB27A.,function:Rab GTPase effector involved in the late steps of regulated exocytosis, both in endocrine and exocrine cells (By similarity). Acts as a potential RAB3B effector protein in epithelial cells.,similarity:Contains 1 FYVE-type zinc finger.,similarity:Contains 1 RabBD (Rab-binding) domain.,subcellular location:Recruited to the vesicle membrane in a GTP-and RAB3B-dependent manner in epithelial cells.,subunit:Recruited to dense-core vesicles through specific interaction with RAB27A in endocrine cells. Interacts with RAB3A, RAB3B, RAB3C and RAB3D. Interacts with ZYX.,tissue specificity:Moderate to high levels of expression in thyroid, ovary, stomach, heart, pancreas, skeletal muscle, kidney and liver. Also detected in epithelial cells., |
| Subcellular location | Cytoplasm . Cytoplasmic vesicle, secretory vesicle membrane . Recruited to the vesicle membrane in a GTP- and RAB3B-dependent manner in epithelial cells. |
| Expression | Moderate to high levels of expression in thyroid, ovary, stomach, heart, pancreas, skeletal muscle, kidney and liver. Also detected in epithelial cells. |
Additional Images
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Western blot analysis of lysates from SW480 cells, primary antibody was diluted at 1:1000, 4°over night
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: AO-06-ES13335-50
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