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Antibody Product Overview
| ELK.No | ES13366 |
| Product name | RN5A rabbit pAb |
| Reactivity | Human; Mouse |
| Applications | WB |
| Other name | |
| Size | 50μL |
| Unit price ($) | 148 |
| Human gene ID | 6041 |
| Human Swiss-Prot | Q05823 |
| Source | Rabbit |
| Isotype | IgG |
| Target | RN5A |
| Fields | >>NOD-like receptor signaling pathway;>>Hepatitis C;>>Influenza A;>>Herpes simplex virus 1 infection |
| Gene name | RNASEL RNS4 |
| Protein name | RN5A |
| Human gene link | View Human Gene |
| Human Swiss link | View Human Swiss-Prot |
| Mouse gene ID | 24014 |
| Mouse gene link | View Mouse Gene |
| Mouse Swiss-Prot | Q05921 |
| Mouse Swiss link | View Mouse Swiss-Prot |
| Rat gene ID | |
| Rat gene link | |
| Rat Swiss-Prot | |
| Rat Swiss link | |
| Immunogen | Synthesized peptide derived from human RN5A AA range: 248-298 |
| Specificity | This antibody detects endogenous levels of RN5A at Human/Mouse |
| Formulation | Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide. |
| Clonality | Polyclonal |
| Dilution | WB 1：500-2000 |
| Purification | The antibody was affinity-purified from rabbit serum by affinity-chromatography using specific immunogen. |
| Concentration | 1 mg/ml |
| Storage stability | -20°C/1 year |
| Molecular Weight (Da) | 82kD |
| Observed band (KD) | |
| Background | This gene encodes a component of the interferon-regulated 2-5A system that functions in the antiviral and antiproliferative roles of interferons. Mutations in this gene have been associated with predisposition to prostate cancer and this gene is a candidate for the hereditary prostate cancer 1 (HPC1) allele. [provided by RefSeq, Jul 2008], |
| Function | catalytic activity:Cleaves 3' of UpNp dimers, with preference for UU and UA sequences, to sets of discrete products ranging from between 4 and 22 nucleotides in length.,cofactor:Manganese or magnesium. Required for optimal RNA cleavage rates.,disease:Defects in RNASEL may be the cause of susceptibility to hereditary prostate cancer 1 (HPC1) [MIM:176807, 601518].,domain:The nine ankyrin repeats also called 2-5A sensor constitute the 2-5A binding domain.,domain:The protein kinase domain is predicted to be catalytically inactive. It allows the homodimerization.,enzyme regulation:After binding to 2-5A (5'-phosphorylated 2',5'-linked oligoadenylates) the homodimerization and subsequent activation occurs. Inhibited by RNase L inhibitor.,function:Endoribonuclease, mediator of interferon action, which play a role in mediating resistance to virus infection and apoptosis. Might play a central role |
| Subcellular location | Cytoplasm . Mitochondrion . |
| Expression | Highly expressed in spleen and thymus followed by prostate, testis, uterus, small intestine, colon and peripheral blood leukocytes. |
Additional Images
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Western blot analysis of lysates from AD293 cells, primary antibody was diluted at 1:1000, 4°over night
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: AO-06-ES13366-50
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