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Nuclear Receptor NR4A1 (Phospho-Ser351) Rabbit pAb
AO-06-ES14439-50
Antibody Product Overview
| ELK.No | ES14439 |
| Product name | Nuclear Receptor NR4A1 (Phospho-Ser351) Rabbit pAb |
| Reactivity | Human; Mouse; Rat |
| Applications | WB; ELISA |
| Other name | Nuclear receptor subfamily 4 group A member 1 (Early response protein NAK1;Nuclear hormone receptor NUR/77;Nur77;Orphan nuclear receptor HMR;Orphan nuclear receptor TR3;ST-59;Testicular receptor 3) |
| Size | 50μL |
| Unit price ($) | 148 |
| Human gene ID | 3164 |
| Human Swiss-Prot | P22736 |
| Source | Rabbit |
| Isotype | IgG |
| Target | Nur77 |
| Fields | >>MAPK signaling pathway;>>PI3K-Akt signaling pathway;>>Aldosterone synthesis and secretion;>>Cortisol synthesis and secretion;>>Cushing syndrome |
| Gene name | NR4A1 GFRP1 HMR NAK1 |
| Protein name | Nuclear Receptor NR4A1 (Phospho-Ser351) |
| Human gene link | |
| Human Swiss link | View Human Swiss-Prot |
| Mouse gene ID | |
| Mouse gene link | |
| Mouse Swiss-Prot | |
| Mouse Swiss link | |
| Rat gene ID | |
| Rat gene link | |
| Rat Swiss-Prot | |
| Rat Swiss link | |
| Immunogen | Synthesized pospho peptide derived from human Nuclear Receptor NR4A1 (Phospho-Ser351) |
| Specificity | This antibody detects endogenous pospho levels of human Nuclear Receptor NR4A1 (Phospho-Ser351) |
| Formulation | Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide. |
| Clonality | Polyclonal |
| Dilution | WB 1:500-2000, ELISA(peptide)1:5000-20000 |
| Purification | The antibody was affinity-purified from mouse ascites by affinity-chromatography using specific immunogen. |
| Concentration | 1 mg/ml |
| Storage stability | -20°C/1 year |
| Molecular Weight (Da) | |
| Observed band (KD) | 77kD |
| Background | This gene encodes a member of the steroid-thyroid hormone-retinoid receptor superfamily. Expression is induced by phytohemagglutinin in human lymphocytes and by serum stimulation of arrested fibroblasts. The encoded protein acts as a nuclear transcription factor. Translocation of the protein from the nucleus to mitochondria induces apoptosis. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jan 2011], |
| Function | function:Orphan nuclear receptor.,induction:By growth-stimulating agents.,similarity:Belongs to the nuclear hormone receptor family.,similarity:Belongs to the nuclear hormone receptor family. NR4 subfamily.,similarity:Contains 1 nuclear receptor DNA-binding domain.,subunit:Interacts with GADD45GIP1.,tissue specificity:Fetal muscle and adult liver, brain and thyroid., |
| Subcellular location | Nucleus . Cytoplasm . Mitochondrion . Nuclear export to the cytoplasm is XPO1-mediated and positively regulated by IFI27 (PubMed:22427340). Translocation to the mitochondrion upon interaction with RXRA and upon the presence of 9-cis retinoic acid (PubMed:17761950). . |
| Expression | Fetal muscle and adult liver, brain and thyroid. |
Additional Images
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Western blot analysis of various lysates, primary antibody was diluted at 1:1000, 4° over night, secondary antibody(cat: RS23920)was diluted at 1:10000, 37° 1hour.
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: AO-06-ES14439-50
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