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Antibody Product Overview
| ELK.No | ES14448 |
| Product name | NSD3 rabbit pAb |
| Reactivity | Human; Mouse |
| Applications | WB |
| Other name | |
| Size | 50μL |
| Unit price ($) | 148 |
| Human gene ID | 54904 |
| Human Swiss-Prot | Q9BZ95 |
| Source | Rabbit |
| Isotype | IgG |
| Target | NSD3 |
| Fields | >>Lysine degradation;>>Metabolic pathways |
| Gene name | WHSC1L1 NSD3 DC28 |
| Protein name | NSD3 |
| Human gene link | View Human Gene |
| Human Swiss link | View Human Swiss-Prot |
| Mouse gene ID | 234135 |
| Mouse gene link | View Mouse Gene |
| Mouse Swiss-Prot | Q6P2L6 |
| Mouse Swiss link | View Mouse Swiss-Prot |
| Rat gene ID | |
| Rat gene link | |
| Rat Swiss-Prot | |
| Rat Swiss link | |
| Immunogen | Synthesized peptide derived from human NSD3 AA range: 1373-1423 |
| Specificity | This antibody detects endogenous levels of NSD3 at Human/Mouse |
| Formulation | Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide. |
| Clonality | Polyclonal |
| Dilution | WB 1：500-2000 |
| Purification | The antibody was affinity-purified from rabbit serum by affinity-chromatography using specific immunogen. |
| Concentration | 1 mg/ml |
| Storage stability | -20°C/1 year |
| Molecular Weight (Da) | 158kD |
| Observed band (KD) | |
| Background | This gene is related to the Wolf-Hirschhorn syndrome candidate-1 gene and encodes a protein with PWWP (proline-tryptophan-tryptophan-proline) domains. This protein methylates histone H3 at lysine residues 4 and 27, which represses gene transcription. Two alternatively spliced variants have been described. [provided by RefSeq, May 2015], |
| Function | catalytic activity:S-adenosyl-L-methionine + histone L-lysine = S-adenosyl-L-homocysteine + histone N(6)-methyl-L-lysine.,disease:A chromosomal aberration involving WHSC1L1 is found in childhood acute myeloid leukemia. Translocation t(8;11)(p11.2;p15) with NUP98.,disease:Defects in WHSC1L1 may be involved in non small cell lung carcinomas (NSCLC). Amplified or overexpressed in NSCLC.,function:Histone methyltransferase. Preferentially methylates 'Lys-4' and 'Lys-27' of histone H3. H3 'Lys-4' methylation represents a specific tag for epigenetic transcriptional activation, while 'Lys-27' is a mark for transcriptional repression.,sequence caution:Contaminating sequence. Potential poly-A sequence.,similarity:Belongs to the histone-lysine methyltransferase family. SET2 subfamily.,similarity:Contains 1 AWS domain.,similarity:Contains 1 post-SET domain.,similarity:Contains 1 SET domain.,similari |
| Subcellular location | Nucleus . Chromosome . |
| Expression | Highly expressed in brain, heart and skeletal muscle. Expressed at lower level in liver and lung. |
Additional Images
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Western blot analysis of lysates from 293T cells, primary antibody was diluted at 1:1000, 4°over night
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: AO-06-ES14448-50
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